Neurodegenerative diseases features

It shows significant activity against a spectmm of neurodegenerative disorders in animal models that replicate many of the features of important human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Parkinson s disease [147]. 

There is a common feature in the two major neurodegenerative diseases In both Alzheimer s disease (AD) and Parkinson s disease (PD) there is an imbalance of metal metabolism leading to oxidative stress-induced neuronal apoptosis. It is well known that there is no cure or efficient treatment available for these diseases. Is there a way to prevent these diseases From this review... 

Pathological activation of glutamate receptors is a common feature and one of the primary causes of neuronal death in acute neuronal injury (such as trauma, epilepsy, and brain ischemia) and chronic neurodegenerative diseases (such as Parkinson s disease, Alzheimer diseases, amyotrophic lateral sclerosis, and AIDS dementia) (Choi, 1988 Doble, 1999 Lipton and Rosemberg, 1994). In particular, elevation of extracellular glutamate level is a key factor in the development of neuronal damage under ischemic conditions. 

A broad array of human neurodegenerative diseases share strikingly similar histopathological features, e.g., the presence of insoluble protein deposits, such as the neurofibrillary tangles and neuritic plaques of Alzheimer s disease, the Lewy bodies of Parkinson s disease, and the intranuclear inclusions of Huntington s disease [42]. 

Abnormalities in cell death regulation can be a significant component of diseases such as cancer, autoimmune lymphoproliferative syndrome, AIDS, ischemia, and neurodegenerative diseases such as Parkinson s disease, Alzheimer s disease, Huntington s disease, and amyotrophic lateral sclerosis. Some conditions feature insufficient apoptosis, whereas others feature excessive apoptosis. 

Halliwell B (2006) Proteasomal Dysfunction A Common Feature of Neurodegenerative Diseases Implications for the Environmental Origins of Neurodegeneration. Antioxid Redox Signal... 

At the beginning there seemed to be no common feature to all these diseases, but since about 1963 the fact that protein aggregates could be found in a wide variety of neurodegenerative diseases gained recognition, when Orgel presented the thesis, that accumulated proteins lead to senescence of cells through toxic accumulation. [4,23]. 

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