Lewy body

Dementia with Lewy bodies (DLB) is considered the second most common cause of dementia after AD. The disorder is characterized by progressive fluctuating cognitive impairment, visual hallucinations and motor features of Parkinsonism. Neocoitical cholinergic activity is more severely depleted in DLB than in AD, and DLB also affects the caudate nucleus, the thalamus and the brain stem. Tolerability of ChEI in DLB appears similar to AD, with some gastrointestinal effects and muscle cramps. 

Lewy bodies are typical in neuronal degeneration, which is accompanied by the presence of these eosinophilic intracellular inclusions of 5-25 pm diameter in a proportion of still surviving neurons. Lewy bodies contain neurofilament, tubulin, microtubule-associated proteins 1 and 2, and gelsolin, an actin-modulating protein. 

Lewy bodies Abnormal masses inside some nerve cells. They occur in a variety of locations, and their structure and composition vary depending on location. 

Diffuse Lewy body Cerebrocortical regions, a-Synuclein Lewy bodies and neurites... 

Wakabayashi K, Hansen LA, Vincent I, Mallory M, Masliah E. Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer s disease, Lewy body disease and progressive supranuclear palsy. Acta Neuropathol Berl 1997 93 7-12. 

Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson s disease and dementia with Lewy bodies. Am J Pathol 1998 152 879-884. 

Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PT, Goedert M. Filamentous a-synuclein inclusions link multiple system atrophy with Parkinson s disease and dementia with Lewy bodies. Neurosci Lett 1998 251 205-208. 

Baumann C., Dauvilliers Y., Mignot E., Bassetti C. (2004). Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness. Eur. Neurol. 52, 73-6. 

Turner R., DAmato C., Chervin R., (2000). Blaivas M. The pathology of REM-sleep behavior disorder with comorbid Lewy body dementia. Neurology 55, 1730-2. 

The genetics of Lewy body dementia remains largely uncertain 659... 

McKeith, I. G., Galasko, D., Kosaka, K. etal. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) report of the consortium on DLB international workshop. Neurology 47 1113— 1124,1996. 

Hamilton, R. L. Lewy bodies in Alzheimer s disease a neuro-pathological review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol. 10 378-384,2000. 

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