Neurobiological development

Another line of research is focused on the neurobiological development of the human brain in relation to schizophrenia. It has been hypothesised that schizophrenia is due to abnormal neurodevelopment, which results in a static encephalopathy that usually becomes manifest in adolescence. This abnormal development leads to morphological deviations such as enlarged or reduced brain structures, a disrupted communication between different brain structures, alterations in neuron density or decreased neuron size, and abnormal neuronal... 

Sevarino KA, Oliveto A, Kosten TR Neurobiological adaptations to psychostimulants and opiates as a basis of treatment development. Ann N Y Acad Sci 909 51 —87,2000 Silberman EK, Reus VI, Jimerson DC, et al Heterogeneity of amphetamine response in depressed patients. AmJ Psychiatry 138 1302—1307, 1981 Sofuoglu M, Brown S, Babb DA, et al Depressive symptoms modulate the subjective and physiological response to cocaine in humans. Drug Alcohol Depend 63 131-137, 2001... 

In the first section of the Review, the basic neurobiology of PCP was emphasized. Studies on the binding of PCP to specific receptor molecules in brain have been confounded by the presence of two types of PCP-binding molecules. GUNDLACH reported that he was able to distinguish a PCP-binding site from an opiate-binding site that also binds PCP. The two sites had different localizations in brain and produced different behaviors. ZUKIN also separated the two receptors and reported on the early development of the PCP receptor in brain. He described the isolation from brain of a substance that reacts specifically with the PCP receptor. 

Nemeroff CB (2002). New directions in the development of antidepressants The interface of neurobiology and psychiatry. Human Psychopharmacology, 17(Suppl. 1), S13-S16. 

Addiction A primary chronic neurobiologic disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations. It is characterized by behaviors that include one or more of the following 5Cs chronicity, impaired control over drug use, compulsive use, continued use despite harm, and craving. 

Abstract In situ hybridisation is a powerful technique for determining the distribution of specific mRNA species in tissues such as brain that comprise different cell types. Its utility in molecular neurobiology has driven the development of a variety of variations of this technique will be reviewed. 

PTSD pharmacotherapy has been an area of intense research interest over the past decade. This has been complemented by a plethora of studies regarding the neurobiology of the disorder that may ultimately serve to inform the development and refinement of novel therapies. Pharmacotherapy is used to target one or more of the main PTSD symptom clusters, that is, reexperiencing symptoms, avoidance/numbing symptoms, and hyperarousal symptoms. 

Bohus M, Schmahl C, Lieb K. New developments in the neurobiology of borderline personality disorder. Curr Psychiatry Rep 2004 6(1) 43-50. 

Develop research on hormonally mediated neurobiologic function in order to understand gender differences predisposing women to experience decreased resiliency to fear-provoking stimuli... 

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