Nerve agent pretreatments

Keeler, J. R. (1990). Interactions between nerve agent pretreatment and drugs commonly used in combat anesthesia. Military Medicine, 155, 527-533. 

Keeler, J. R., Hurst, C. G., Dunn, M. A. (1991). Pyridostigmine used as a nerve agent pretreatment under war time conditions. Journal of the American Medical Association, 266, 693-695. 

Fricke, R.F. et al.. Efficacy of tacrine as a nerve agent pretreatment. Drug Chem. Toxicol., 17, 15, 1994. 

Keeler JR, Hurst CG, Dunn MA Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA 266 693-695, 1991 Labbate LA, Snow MP Posttraumatic stress symptoms among soldiers exposed to combat in the Persian Gulf. Hospital and Community Psychiatry 43 831-833,... 

Buchholz, B. A., Pawley, N. H, Vogel. J, S., and Mauihe, R. J. (1997). Pyrethroid decrease in central nervous system from nerve agent pretreatment. X A/j/)/. Toxicol. 17,231-234. 

To minimize such problems, continuous training is required so that soldiers are comfortable donning their protective equipment and operating in a chemically contaminated environment. Similarly, soldiers must understand the rationale for taking the nerve agent pretreatment, pyridostigmine, as an... 

The major reason for interest in biotechnolog-ically derived nerve agent pretreatments lies in their... 

The inadequacy of postexposure therapy for nerve agent casualties, particularly those with potentially lethal exposures to soman, has been of great concern. Development of pyridostigmine, a peripherally active carbamate compound, as a nerve agent pretreatment adjunct has substantially improved the ability of the U.S. military to protect its soldiers from the lethal effects of nerve agents. A major deficiency of this pretreatment program—that it does not protect the CNS against... 

In 1990, the Iraqi Army invaded neighboring Kuwait. Subsequently, the United States, at the request of Saudi Arabia, led a coalition to send forces to the area (Smart, 1997). These forces were the largest to operate in a potential chemical environment since World War I. They were provided witii atropine autoinjectors, an acetylcholinesterase reactivator, and a nerve agent pretreatment (p5nidostig-mine bromide). Fortunately, chemical weapons apparently were not used in this conflict, although multiple false alarms were reported. The failure of the Iraqi military... 

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