4- Nefazodone

Coadministration with most medications that are metabolized by CYP 3A3/4 should be undertaken with caution, and the doses of the other medications that are CYP 3A3/4 substrates (see Table 1-1) should be reduced. The interaction between nefazodone and MAOIs has not yet been evaluated, but it may be as dangerous as 

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Atypical Antidepressants. StmcturaHy diverse dmgs such as the tetracyclic mianserin (46) and various bicyclic and tricyclic compounds such as trazodone (47), venlafaxine (48), nefazodone (49), and amfebutamone (50) are atypical antidepressants. The exact mechanism of action is unclear but probably... 

CijHijNjOi 95885-13-5) see Nefazodone hydrochloride l-ethyl-l,4-dihydro-5f/-tetrazol-5-one (C,H4N40 69048-98-2) see Alfentanil ethyldiisopropylamine... 

C5H9NO 10431-98-8) see Nefazodone hydrochloride ( )-ethyl 2-oxo-3-benzoylamino-3-phenylpropionate (C H,7N04 153433-79-5) see Paclitaxel ethyl 3-oxocaproatc... 

C2H N202 6294-89-9) see Nefazodone hydrochloride D(-)-methyl 3-(a-carboxybenzylamino)crotonate sodium salt... 

C11H15NO2 99153-71-6) see Nefazodone hydrochloride /V-(2-phenoxyethyl)-2-thiophenemcthanamine (CijHjjNOS) see Thenium closiiate... 

Using a within-subject, placebo-controlled design, Haney et al. (2003) recently reported that nefazodone, an antidepressant that also has some sedative properties, decreased reports of anxiety and muscle pain during closely mon-... 

Antidepressants Desipramine, imipramine, sertraline, fluoxetine, paroxetine, venlafaxine, bupropion, nefazodone, mirtazapine, gepirone, amineptine Mixed findings suggest that better designed studies may find a niche for some of these drugs. Amineptine was effective for withdrawal symptoms. 

Ciraulo DA, Rotrosen J, Leiderman D, et al Nefazodone induced alterations of cocaine craving and use in dysphoric cocaine users. Drug Alcohol Depend 60 S38, 2000 Connell PH Amphetamine Psychosis (Maudsley Monographs No 5). London, Oxford University Press, 1938... 

Economic analysis of treating depression with nefazodone v. imipramine. Br J Psychiatry 168, 768-71. 

Rotzinger, S, Bourin, M, Akimoto, Y, Coutts, RT and Baker, GB (1999) Metabolism of some second and fourth generation antidepressants iprindole, viloxazine, buproprion, mianserin, maprotiline, trazodone, nefazodone and venlafaxine. Cell. Molec. Neurobiol. 19 427 42. 

Acetaminophen, bosentan, diclofenac, isoniazid, lovastatin, methyldopa, niacin, nefazodone, phenytoin, propylthiouracil, rifampin, trazodone, valproic acid, and venlafaxine... 

Specific concomitant medications or consumptions (check specific statin package insert for warnings) fibrates (especially gemfibrozil, but other fibrates too), nicotinic acid (rarely), cyclosporine, azole antifungals such as itraconazole and ketoconazole, macrolide antibiotics such as erythromycin and clarithromycin, protease inhibitors used to treat Acquired Immune Deficiency Syndrome, nefazodone (antidepressant), verapamil, amiodarone, large quantities of grapefruit juice (usually more than 1 quart per day), and alcohol abuse (independently predisposes to myopathy)... 

Bupropion Venlafaxine Duloxetine Trazodone Nefazodone Mirtazapine... 

Trazodone routinely causes sedation, which is why it is used far more often as an adjunct with other antidepressants for sleep than as a primary agent for the treatment of depression. Priapism is a rare but serious adverse effect in males who take trazodone. In addition, orthostatic hypotension and dizziness are more common with trazodone than with nefazodone because the latter agent has a weaker effect at a-adrenergic receptors and also has a balancing of adrenergic effects owing... 

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