Nefazodone drug withdrawal

Antidepressants Desipramine, imipramine, sertraline, fluoxetine, paroxetine, venlafaxine, bupropion, nefazodone, mirtazapine, gepirone, amineptine Mixed findings suggest that better designed studies may find a niche for some of these drugs. Amineptine was effective for withdrawal symptoms. 

The substantial fall in plasma zopiclone concentration after withdrawal of nefazodone probably reflected a drug interaction due to inhibition of CYP3A4 by nefazodone (38). Despite the normally short half-life of zopiclone, the residual sedation initially observed in this case suggests that the interaction had clinical significance. 

In 12 healthy volunteers, there were no clinically significant alterations in blood concentrations of lithium or nefazodone and its metabolites when the drugs were coadministered (587). The addition of lithium for 6 weeks to nefazodone in 14 treatment-resistant patients produced no serious adverse effects and no dropouts (588). Lithium augmentation of nefazodone in 13 treatment-resistant depressed patients was associated with a variety of annoying adverse effects, but none led to treatment withdrawal (589). 

The substantial fall in plasma zopiclone concentration after withdrawal of nefazodone probably reflected a drug interaction due to inhibition of CYP3A4 by... 

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