Need to Coordinate Cytotoxicity Screening with Other Discovery Safety Assessments

Recognition of the importance of safety attrition and how it could be reduced by discover toxicology programs has only occurred recently. Thus, it is relatively new. 

Need to Coordinate Cytotoxicity Screening with Other Discovery Safety Assessments 

After in silico and in vitro screening, short-term in vivo toleration (IVT) studies [7] are conducted to identify unexpected target organ toxicities, such as myelotoxicity and hepatotoxicity. The IVT is essentially an abbreviated version of regulatory, preclinical. 

Scholarship Evaluation of historical safety issues associated with chemical structure or molecular target 

Physico-chemical properties Toxicity potential has been demonstrated to be substantially decreased with compounds with low molecular weights and low polarity and lipophilicily 

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