Nausea miconazole

Administration of miconazole for a vulvovaginal fungal infection may cause irritation, sensitization, or vulvo-vaginal burning. Skin irritation may result in redness, itching, burning, or skin fissures. Other adverse reactions with miconazole include cramping, nausea, and headache Adverse reactions associated with topical use are usually not severe. 

Cartwright [124] reported that miconazole was slightly absorbed from epithelial and mucosal surface. The drug is well absorbed from the gastrointestinal tract, but caused nausea and vomiting in some patients. The drug may be given intravenously but was associated phlebitis. Up to 90% of the active compound was bound to plasma protein. Distribution into other body compartments was poor. Metabolism was primarily in the liver, and only metabolites were excreted in the urine. At therapeutic levels, they were relatively nontoxic both locally and systematically, but occasionally produced disturbances on the central nervous system. 

Topical miconazole is well tolerated. Parenteral administration carries a higher frequency of adverse effects, some probably being caused by Cremophor (polyethoxylated castor oil, the carrier). Adverse effects include fever, chills, pruritus, rash, nausea, vomiting, diarrhea, hjrpona-tremia, cardiac toxicity, phlebitis, hyperhpidemia, and central nervous system disturbances. Hypersensitivity reactions can occur. Tumor-inducing effects have not been reported. 

This drug is indicated for infections of skin and nails due to dermatophytes or Candida species and vulvovaginal infections due to Candida species. Miconazole is used orally for prophylactic purposes in patients who have been treated with cytostatics or immunosuppressants, in particular, to prevent candidosis of the mouth and digestive tract. Side effects include possible nausea during oral treatment. Miconazole tablets may increase the anticoagulant effect of coumarin derivatives. Topical treatment with cream or powder is well tolerated. Local irritation and alleigic reactions of the skin and mucosa occur only rarely. 

Miconazole (Monistat) Vaginal candidiasis, severe systemic fungal infections. Phlebitis, pruritus, nausea, fever, rash, vomiting (if intravenous). 

Imidazoles arc wide-spectnim antifungal drugs to which resistance rarely develops. Except for ketoconazolc. the imidazoles are poorly absorbed orally. Clotrimazole, econii/ule and miconazole are widely used lopic-aliy in the Ireatment of dennaiophyle and Candida alhicam infections. Miconazole is used intravenously in systemic infections in patients who cannot tolerate amphotericin. It may cause nausea and vomiting, faintness and anaphylaxis. Ketoconazole is well absorbed orally, and has been used in Ihe crealment of local and systemic mycoses. Enthusiasm for ketoconazole has declined because it may cause hepatic necrosis and adrenal suppression. 

A brief report (32 ) of the use of systemic miconazole in the treatment of human coccidioidomycosis, showed that phlebitis occurred in more than half the patients and was severe enough to stop treatment in several. Dizziness, blurred vision, nausea, and a maculopapular rash were also reported in a few patients. All the adverse effects reversed with cessation of treatment. A second report (33 ) from the United States described thrombocytosis and anaemia in 3 patients with coccidioidomycosis treated with intravenous miconazole. The abnormalities were reproducible on rechallenge with the compound (see also Chapter 25). 

---