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Natural products, representation

The rationale underlying the representation of the variety of natural products through their skeletons has been outlined early in Part III. Then, the variety of natural products has been illustrated in charts... [Pg.99]

Most of the recent literature in this field is concerned with synthetic organic reactions, supramolecular chemistry and crystal engineering. However, solvent free approaches can also be used in the extraction of natural products, although less information is available in the mainstream literature. Juice extractors can be used to afford aqueous solutions of biologically active compounds from undried plant material. An extract of Capsicum annum L. was recently prepared in this way, and then used in the green synthesis of silver nanoparticles. The actual synthesis of the nanoparticles was conducted in the aqueous phase and therefore this work will not be discussed further here. However, this solvent free approach to extraction is probably worthy of greater representation in the green chemistry literature. [Pg.24]

These are some examples of the analysis that can be performed for three representative datasets in Table 2.2. Similar analysis using these or other molecular representations can be conducted for other databases. In fact, a comparison of the collection of drugs analyzed here with natural products and compounds obtained from PubChem has been published elsewhere (Singh et ah, 2009). [Pg.43]

Figure 11 Conceptualized representation of bioassay-guided fractionation (BGF) as applied to isolation of a plant natural product. Application to a library component would start with the fractionation step. Figure 11 Conceptualized representation of bioassay-guided fractionation (BGF) as applied to isolation of a plant natural product. Application to a library component would start with the fractionation step.
FIGURE 9.10 Tree-like graphical representation of natural product scaffolds. For clarity, only scaffolds that cumulatively represent at least 0.2% of the natural products in the DNP are shown. [Pg.196]

The three types of PKSs described here, the enediyne PKS, the C-0 bondforming PKS, and the AT-less PKS, are only representive examples that reside outside the archetypical PKS paradigms. Continued exploration on the mechanism of polyketide biosynthesis will undoubtly uncover more unusual PKSs. These novel PKSs, in combination with the archetypical ones, will ultimately enhance the toolbox available to facilitate combinatorial biosynthesis and production of iinnatural natural products. The full realisition of the potential embodied by combinatorial biosynthesis of PKSs for natural product structural diversity, however, depends critically on the fundamental characterization of PKS structure, mechanism, and catalysis. [Pg.164]

Figure 47 Representive natural products of arthropod (17,142,196,197) and microbial (14,198) origin. Figure 47 Representive natural products of arthropod (17,142,196,197) and microbial (14,198) origin.
A better representation of the effectiveness of the additives is given in Fig. 5.12 which shows the actual material efficiency of each additive after the first 100 cycles. Additives which had a better initial performance at the lower concentration of 0.25 wt.%, such as Lomar B, Vanisperse A, and Maracell XC-2, maintained efficiencies that were greater than 100 mAh g after 100 cycles. At the higher concentrations (0.75wt.%), the utilization of negatives with synthetic materials Lomar and GKD was about 20% higher than most of the natural products. In most cases, but particularly with the natural products, the material utilization was higher when cells were cycled at 40° C. With the synthetic material Lomar B, there was little difference in utilization at the two temperatures. [Pg.152]

On a point of interest, the Cambridge Structural Database (8) archives crystal structure data (currently approx 153,000 small molecules) and enables searches to be performed using a graphical interface. Entries for terpenes, alkaloids, and miscellaneous natural products are identified as such, which is useful for searching these classes of compounds. The number of compounds in these three categories, with coordinates to enable 3D representation of structure, currently stands at approx 3700. [Pg.266]

While there is no universally accepted scientific terminology for representation there is general agreement on a certain working nomenclature (refs. 97,98). Thus a-tocopherol, the natural stereoisomer is as stated earlier (RRR)-a-tocopherol, the 2-epimer is 2-epi-a-tocopherol and a mixture of (RRR) and (SRR)-a-tocopherols is 2-ambo-a-tocopherol. Synthetic a-tocopherol prepared from synthetic phytol or isophytol is called all-rac-a-tocopherol, since it is theoretically a mixture of (RRR) and (SSS). The mixture of reduction products of 5,7,8-trimethyltocotrienol is called 4 -ambo-8 -ambo-a-tocopherol since as a natural product, although it has a 2R centre, the stereochemistry from hydrogen addition at the 4- and 8- positions is probably substantially RS. [Pg.441]

The ability to assign a group of vibrational/rotational energy levels implies that the complete Hamiltonian for these states is well approximated by a zero-order Hamiltonian which has eigenfunctions /,( i)- The are product functions of a zero-order orthogonal basis for the molecule, or, more precisely, product functions in a natural basis representation of the molecular states, and the quantity m represents the quantum numbers defining tj>,. The wave functions are given by... [Pg.41]

Scheme 11.53. A cartoon representation of a potential pathway to aristolone from farnesyl diphosphate.The pattern of methylation anticipated has changed due to (presumably) a series of hydride and methide shifts. The structure of aristolochic acid, one of the few nitro-containing natural products known is also shown since some sesquiterpene alcohols are found as esters. Scheme 11.53. A cartoon representation of a potential pathway to aristolone from farnesyl diphosphate.The pattern of methylation anticipated has changed due to (presumably) a series of hydride and methide shifts. The structure of aristolochic acid, one of the few nitro-containing natural products known is also shown since some sesquiterpene alcohols are found as esters.

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