Miscellaneous Natural Products

Experimental procedures have been described in which the desired reactions have been carried out either by whole microbial cells or by enzymes (1—3). These involve carbohydrates (qv) (4,5) steroids (qv), sterols, and bile acids (6—11) nonsteroid cycHc compounds (12) ahcycHc and alkane hydroxylations (13—16) alkaloids (7,17,18) various pharmaceuticals (qv) (19—21), including antibiotics (19—24) and miscellaneous natural products (25—27). Reviews of the microbial oxidation of aUphatic and aromatic hydrocarbons (qv) (28), monoterpenes (29,30), pesticides (qv) (31,32), lignin (qv) (33,34), flavors and fragrances (35), and other organic molecules (8,12,36,37) have been pubflshed (see Enzyp applications, industrial Enzyt s in organic synthesis Elavors AND spices). 

Miscellaneous Natural Products. The longhst of natural products used in early cough preparations has diminished to the point where only a few are still mentioned. Four natural products stiU used occasionally outside the United States ate squill, hotehound, cociEana, and ipecac. 

Interestingly, several natural products, besides their role as antibiotics and phytotoxins, exhibit plant growth responses (mainly inhibition). In order to keep their identity as such, these were listed under miscellaneous natural products (Table 1). Furthermore, compounds which have structural features similar to those present in hormones (gibberellins and ABA.) and which exhibit similar growth responses are also listed under miscellaneous natural products (Table 1). 

K. Mori, Ed., Comprehensive Natural Products Chemistry, Vol. 8 Miscellaneous Natural Products including Marine Natural Products, Pheromones, Plant Hormones, and Aspect of Ecology, Elsevier Oxford, 1999 pp 1-749. 

M. Suffness J. Douros. Miscellaneous Natural Products with Antitumor Activity. In Anticancer Agents Based on Natural Product Models, J. M. Cassady, J. D. Douros, Eds. Academic Press New York, 1980 pp 465-487. 

On a point of interest, the Cambridge Structural Database (8) archives crystal structure data (currently approx 153,000 small molecules) and enables searches to be performed using a graphical interface. Entries for terpenes, alkaloids, and miscellaneous natural products are identified as such, which is useful for searching these classes of compounds. The number of compounds in these three categories, with coordinates to enable 3D representation of structure, currently stands at approx 3700. 

H. Budzikiewicz, C. Djerassi, and D. H. Williams, Structure Elucidation of Natural Products by Mass Spectrometry, vol. I, Alkaloids vol. 11, Steroids, Terpenoids, Sugars, and Miscellaneous Natural Products, San Francisco Holden-Day, 1964. 

However, for class 59 (miscellaneous natural products) cross-referencing is sometimes desirable. 

Miscellaneous natural products containing C, H, O, halogens only. 

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