Natural killer cells properties

Another effector function is the cell-mediated cytotoxicity. Infected cells that were recognized and opsonized by specific antibodies can be lysed by natural killer cells which are the classical K cells. These properties are highly determined by the Fc part of antibodies. IgGl and IgG3 have the highest capacity for cell-mediated cytotoxicity. The effector function of an antibody is frequently used as a mean of antibody recognition. This is especially the case with bacterial proteins such as protein A and protein G that specifically interact with the same domain. Therefore purification can interfere with the antibody effector function. 

Sanqi decoction stimulated the activities of natural killer cells, macrophages, and plaqueforming cells while crude polysaccharides stimulated the activities of only macrophages and plaque-forming cells in mice sanchi-nan-A (a polysaccharide) has activating effects on the reticuloendothelial system as per the carbon clearance test in mice. Similar immunomodulatory properties have recently been reported for the saponin and polysaccharide fractions. 

Immune system immunostimulating properties, role as super antigen change in the number and distribution of cells in the immime system (increase in the number of macrophages, decline in number of NK cells - natural killer cells) development of systemic autoimmune diseases, such as arthritis, hypothyroidism, fibromyalgia formation of antibodies against polymers [24, 31,45,48,60, 66-69]... 

Nickel salts have also been reported to have immunosuppressive properties in rodents, including giving acute thymic involution [389, 390], suppression of T lymphocyte response to T cell mitogens [389], suppression of antibody [389, 391, 392] and interferon production [393] and suppression of natural killer (NK) cell activity [389, 394-397]. 

Natural-killer (NK) cells are a class of lymphocytes distinct in their ability to identify and kill transformed self-cells without priming. Recognition is via receptors that bind unique but common surface molecules induced on these cells. These properties characterize NK cells as unique effectors for use in immunotherapy. 

Fig. 3 Pathogenesis of acute vascular rejection. Activation of endothelium by xenoreactive antibodies (Ab), complement (C), platelets, and perhaps by inflammatory cells (natural killer (NK) cells and macrophages (M0) leads to the expression of new pathophysiologic properties. These new properties, such as the synthesis of tissue factor (TF) and plasminogen activator inhibitortype 1 (PAI-1), promote coagulation the synthesis of E-selectin and cytokines such as I LI a promote inflammation. These changes in turn cause thrombosis, ischemia, and endothelial injury, the hallmarks of acute vascular rejection. (Adapted from Nature 1998 392(Suppl.) 11-17, with permission.) (See Color Plate p. xxiii).

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