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Nasal peptide absorption, factors

Additional factors influencing nasal peptide absorption include particle residence time and formulation pH and osmolarity. Ohwaki et al (10) measured the effect of solution pH and osmolarity on the intranasal absorption of secretin, a 27 amino acid peptide, in rats. Nasal secretin absorption, as measured by pancreatic secretion rates, was maximal at a formulation pH of 3.0 almost eight times greater than at neutral pH. Solution osmolarity had less effect overall on secretin absorption, maximal absorption occurring in a hyperosmolar saline solution of 0.462 M. [Pg.303]

Ilium, L. (1992), Nasal delivery of peptides, factors affecting nasal absorption, in Topics in Pharmaceutical Sciences, Medpharm Scientific, Stuttgart, p. 71. [Pg.641]

There are two major barriers in the mucosal absorption of peptide and protein—a penetration barrier and an enzymatic barrier (as supported by Lee ), which are relevant to nasal delivery. Taking those into consideration, basic factors influencing the nasal absorption of peptide and protein drugs will be discussed in this section. [Pg.2683]

Peptide and protein nasal drug delivery have challenges related to their unique physical and chemical properties and comprise issues of chemical stability, loss due to physical absorption (especially for low-dose/high-potency molecules) and self-aggregation. The two key factors for nasal delivery of peptides are molecular mass and lipophilicity. The transitional area between a predicted good absorption and a predicted increasing difficulty of absorption is a molecular mass of about 1,000 (McMartin et al. 1987). Complete absorption of a peptide, by... [Pg.508]


See other pages where Nasal peptide absorption, factors is mentioned: [Pg.123]    [Pg.126]    [Pg.216]    [Pg.375]    [Pg.302]    [Pg.2678]    [Pg.120]    [Pg.124]    [Pg.143]    [Pg.946]    [Pg.2678]    [Pg.2701]    [Pg.491]    [Pg.508]    [Pg.228]    [Pg.1710]    [Pg.1712]   


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