Nasal Delivery and Diagnostics

Nasal delivery is a vital input pathway to any organism, including human beings. Three aspects of nasal delivery are important (44)  

Olfactory sensory cells have axons going directly into the central nervous system, and materials introduced into their cytoplasm via transmembrane uptake in the airway therefore have direct access to the brain side of the blood-brain barrier, via anterograde transport within the cells. 

The olfactory sense is of unique importance in controlling behavior, including the behaviors of eating, drinking, and vital social behaviors such as bonding, reproduction, and aggression. 

For aU three of the purposes described above, the precise, digital, interactive, controlled delivery of airborne materials into the nasal airways by solid-state chip-based inkjet dispensing technology is a vital and powerful technique. 

Microdispensing inkjet-based systems permit a precise control of both the temporal envelope of the stimulus and the total number of molecules constituting the stimulus. 

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