Correlation Between Nasal Drug Absorption Models

Correlation Between Nasal Drug Absorption Models 

During the last decade several in vitro models using excised mucosal segments and monolayers of epithelial cells have been established, providing an opportunity to predict nasal drug absorption in vivo while avoiding problems associated with more complex whole animals [8], 

An evaluation of the various studies reported in the literature for preclinical assessment of drugs for nasal administrations indicated the usefulness of in situ, ex vivo, and in vivo approaches. Evidence from the literature also indicates that the choice of a particular model or animal species by different 

Dosage form-related Administration-related Physiological factors factors factors 

Ugwoke MI, Verbeke N, Kinget R (2001) The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol 53 3-21. 

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Correlation Between Nasal Drug Absorption Models... 

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