Tumor-targeting nanoparticles

Shielded polyplexes with improved blood circulating properties are interesting tools for systemic cancer therapy (see Sect. 4.2). Nanoparticles can take advantage of the enhanced permeability and retention (EPR effect) [89] for passive tumor targeting. The EPR effect is based on the leakiness of tumor vasculature, due to neovascularization in growing tumors, combined with an inadequate lymphatic drainage. Nanoparticles with an elongated plasma circulation time can extravasate and passively accumulate at the tumor site. 

Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, Hoebeke J, Duguet E, Colombo P, Couvreur P (2005) Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chemistry 16 1181-1188. 

Devalapally H, Shenoy D, Little S, Langer R, Amiji M (2007) Polyethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of... 

Key Words shRNA RNAi Biodegradable polymer Natural polymer Synthetic polymer Non-viral gene delivery Drug delivery Nanoparticle Microparticle Tumor targeting. 

Devalapally, H., Shenoy, D., Little, S., Langer, R., and Amiji, M. (2007), Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs Part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model, Cancer Chemother. Pharmacol., 59(4), 477-484. 

Qian X, Peng X-H, Ansari DO, Yin-Goen Q, Chen GZ, Shin DM, Yang L, Young AN, Wang MD, Nie S (2008) In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat Biotechnol 26 83... 

Polymeric Nanoparticles. Polymeric nanoparticles are nanoscale aggregates of biocompatible or biodegradable polymers. The size of nanoparticles varies from 10 to 1000 nm, and obviously, particles with a size smaller than 200 nm are preferable for tumor-targeted drug delivery. 

In addition to targeting tumor neovasculature, we also studied the RGD ligand targeted nanoparticle for targeting ocular neovasculature tissues [5]. The antiangiogenesis efficacy observed in ocular neovascularization mcxlels further demonstrated this... 

Park K, Kim JH et al (2007) Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. J Control Release 122 305-314... 

Hwang HY, Kim IS et al (2008) Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release 128 23-31... 

A triggered release of an anticancer drug at tumor pHg (target tumor sites. In general, stable nanocarriers stay in the vicinity of a leaky tumor vasculature after extravasation because of their size (93). Their location can form an obstacle to other nanoparticles, and further accumulation may be prevented. It is assumed that if the nanoparticles disintegrate completely by the time of the subsequent administration, a multiple dose scheme may result in effective tumor targeting. 

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