Tumor targeting properties nanoparticles

Shielded polyplexes with improved blood circulating properties are interesting tools for systemic cancer therapy (see Sect. 4.2). Nanoparticles can take advantage of the enhanced permeability and retention (EPR effect) [89] for passive tumor targeting. The EPR effect is based on the leakiness of tumor vasculature, due to neovascularization in growing tumors, combined with an inadequate lymphatic drainage. Nanoparticles with an elongated plasma circulation time can extravasate and passively accumulate at the tumor site. 

Choi WI, Kim JY, Heo SU, Jeong YY, Kim YH, Tae G (2012) The effect of mechanical properties of iron oxide nanoparticle-loaded functional nano-carrier on tumor targeting and imaging. J Control Release 162 267-275... 

Due to its unique viscoelastic properties, HA is used as a drug delivery vehicle particularly in the form of nanoparticles [64—67]. Figure 1.6 shows an example of self-assembled fluorescently labeled HA nanoparticles, which were used for tumor targeting. HA hydrogels have been used to deliver chemotherapeutics [66, 67], antibiotics [68] and growth factors/proteins [69, 70]. Composites of HA have also... 

In order to maximize therapeutic efficacy while minimizing systemic toxicity, much effort has been placed on the formulation of multifunctional nanoparticles for visuahzation, targeting, and treatment of sohd tumors or inflamed tissue [44]. Of the various components of drug delivery systems (DDSs), the physico-biochemical properties of the dmg carrier (i.e., the formulation), the optimal targeting methodology, and the delivery device are most critical for successful treatment of these diseases. Present multifunctional NPs include carriers... 

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