Nanoparticles ocular drug delivery enhancement

J. Shen, M. Sun, Q. Ping, Z. Ying, W. Liu, Incorporation of liquid lipid in lipid nanoparticles for ocular drug delivery enhancement. Nanotechnology 15 (2010) 1-23. 

The use of polymeric nanoparticles in the eye has gained considerable interests in recent years. Ocular disposition, safety, efficacy, and pharmacokinetic profiles of various nanoparticles offer a wide range of application for the delivery of many drugs used to treat common ocular disorders. Polymeric nanoparticles have been utilized to enhance the performance of ibuprofen and cyclosporine, while reducing systemic side effect of carteolol compared with... 

The synthesis of polyacrylic acid nanoparticles from inverse microemulsions has also been described in the literature. Polyacrylic acid is a well-known bioadhesive agent. Hence, polyacrylic acid nanoparticles loaded with the drug would have enhanced bioavailability and controlled release characteristics. The synthesis of timolol maleate and bri-monidine nanoparticles for improved ocular and oral delivery has been reported [153, 154]. 

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