Ocular drug delivery nanoparticles

De Campos, A.M., et al. 2004. Chitosan nanoparticles as new ocular drug delivery systems In vitro stability, in vivo fate, and cellular toxicity. Pharm Res 21 803. 

Das, S.K., et al. 1995. Evaluation of poly(isobutylcyanoacrylate) nanoparticles for mucoadhesive ocular drug delivery. I. Effect of formulation variables on physicochemical characteristics of nanoparticles. Pharm Res 12 534. 

Kreuter, J. (1990), Nanoparticles as bioadhesive ocular drug delivery systems, in Len-aerts, V., and Gurny, R., Eds., Bioadhesive Drug Delivery Systems, CRC Press, Boca Raton, FL, pp. 203-212. 

Sanchez A, Alonso MJ. Nanoparticulate carriers for ocular drug delivery. In Torchilin VP, ed. Nanoparticles as Drug Carriers. Imperial College Press London 2006 649-673. 

Bourges JL, Gautier SE, Delie F, et al. Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. Invest Ophthalmol Vis Sci 2003 44 3562-3569. 

Zimmer A, Kreuter J. Microspheres and nanoparticles used in ocular drug delivery systems. Adv Drug Deliver Rev 1995 16 61-73. 

The potential of polymeric nanoparticles as an ocular drug delivery system has been explored by a colloidal system consisting of an aqueous suspension of nanoparticles. These nanoparticles can be rapidly fabricated under extremely mild conditions with their ability to incorporate bioactive compounds. ... 

Gupta, H. Aqil, M. Khar, R.K. Ali, A. Bhatnagar, A. Mittal, G. Sparlloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery. Nanomed. Nanotechnol. 2010, 6 (2), 324-333. 

Mahmoud AA, El-Feky GS, Krunel R, Awad GEA. Chitosan/sulfobutylether-P-cyclodextrin nanoparticles as a potential approach for ocular drug delivery. Int J Pharm. 2011 413(l-2) 229-36. 

Gupta H, et al. Biodegradable levofloxacin nanoparticles for sustained ocular drug delivery. J Drug Target 2011 19(6) 409—17. 

F. Li, W. Liu, C. Deng, B. Bareiss, C.R. McLaughhn, and M. Griffith, Collagen-nanoparticle composite for ocular drug delivery and transplantation, http //www.physics.mcgill.ca/ NanoForum/abs/abs-fli-ohri.ca-0.html. 

Poly(acrylic acid) (PAA) (Figure 16.5) is an anionic mucoadhesive polymer produced by the radical polymerization of acrylic add. PAA and its derivatives—weakly crosslinked PAAs, also known as Carbomers or Carbopol—are widely used in ophthalmic formulation, such as the ones used for the management of the dry eye condition. Generally, PAA and its derivatives are used in the preparation of mucoadhesive ocular drug delivery formulations [25], either in the form of viscous gels [26], nanoparticles... 

J. Shen, M. Sun, Q. Ping, Z. Ying, W. Liu, Incorporation of liquid lipid in lipid nanoparticles for ocular drug delivery enhancement. Nanotechnology 15 (2010) 1-23. 

The use of polymeric nanoparticles in the eye has gained considerable interests in recent years. Ocular disposition, safety, efficacy, and pharmacokinetic profiles of various nanoparticles offer a wide range of application for the delivery of many drugs used to treat common ocular disorders. Polymeric nanoparticles have been utilized to enhance the performance of ibuprofen and cyclosporine, while reducing systemic side effect of carteolol compared with... 

Enriquez de Salamanca, A., Diebold, Y., Calonge, M., Garcia-Vazquez, C., Callejo, S., Vila, A., and Alonso, M. J. (2006), Chitosan nanoparticles as a potential drug delivery system for the ocular surface Toxicity, uptake mechanism and in vivo tolerance, Invest. Ophthalmol. Vis. Sci., 47(4), 1416-1425. 

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