Nanoparticles immobilization approaches

Recently, there have been many reports on the effects of CD on metal catalytic systems. A potentially interesting approach for the modification of catalytic systems based on metal complexes, such as Zn, Mo, Fe, In, Sn, Pd or Ru, involves the use of CD as a protective agent. There are many reports on the interaction between CDs and metallic nanoparticles.Immobilized CD on Pd nanoparticles was employed as an efficient mediator in aqueous biphasic hydrogenation reactions (Figure 4.6a,b). ... 

As it is well known, the immobilization of DNA probes onto electrode surfaces is one of the key steps in DNA sensor development. It has been widely demonstrated that the DNA sensor performance (e.g., sensitivity, selectivity, and stability) is highly dependent on the characteristics of DNA probes immobilization approaches. One of these relies on the use of nanomaterials such as gold nanoparticles (Au-NPs), taking advantage of their unique electrical conductivity, biocompatibility, and ease of self-assembly through... 

SERRS spectra of Fe-protoporphyrin IX adsorbed on Ag colloidal nanoparticles immobilized onto a polymer-coated glass slide were obtained at very low concentrations ". The spectra exhibit drastic temporal fluctuations on a time scale of seconds in both line frequency and intensity. This result is consistent with an approach to the single molecule limit. Sequences of spectra were analyzed in terms of an underlying continuum and of Raman peaks superimposed on this continuum. The statistical analysis of the spectrum intensity suggested that the main contribution to the intensity fluctuations arise from the continuum. It was found... 

Scheme 15.42. The approach for preparation of dendron-stabilized metal nanoparticles immobilized on solid support.

Pronkin SN, Tsirlina GA, Petrii OA, Vassiliev SY. 2001. Nanoparticles of Pt hydrosol immobilized on Au support An approach to the study of structural effects in electrocatalysis. Electrochim Acta 46 2343-2351. 

The development of assemblies of inorganic materials with biomolecules has emerged as a novel approach to the controlled fabrication of functionalized nanostructures and networks.5 The practice of DNA sequence detection is especially relevant for forensic sciences, food safety, genetics and other fields.6 The immobilization of single strand DNA probes onto solid materials such as noble metal nanoparticles has proved to be the basis for a multitude of quite different nanobiotech-nological and biomedical applications, including the DNA driven assembly of nanoparticles and biosensors.5-11... 

To arrange AuNPs into a monolayer, Simon and coworkers [74] reported a simple protocol via the oligonucleotides complementary immobiUzation. 5 -Amino-modified oligonucleotide was immobilized on the substrate surface first, and then, 15 nm gold particles modified with thiolated DNA oligomers were coupled to the surface through DNA base pairing. The resulted nanoparticle monolayers were demonstrated to have a thermally activated conductivity. A similar approach has been used to insert a liposome into a DNA chip [75] (Fig. lib). 

---