Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Nafarelin

Fig. 10). A phase separation microencapsulation technique was used to formulate nafarelin acetate in 50 50, 69 31, and 45 55 DL-lactide/glycolide copolymers (120). [Pg.26]

FIGURE 10 Plasma profile of nafarelin acetate and biological response parameter in female Rhesus monkeys after injection with 100 mg of 55 45 lactide/glycolide microspheres. (From Ref. 118.)... [Pg.26]

A series of DL-lactide/glycolide copolymers and the lactide honiopoly-mer were screened in vitro and in vivo with nafarelin. More than 8 months release was achieved with certain implants. [Pg.27]

Eating disorders leuprolide acetate, nafarelin, gosarelin)... [Pg.854]

Prazosin (Minipress) Alfuzosin (Uroxatral) Terazosin (Hytrin) Doxazosin (Cardura) Tamsulosin (Flomax) Finasteride (Proscar) Dutasteride (Avodart) Bicalutamide (Casodex) Flutamide (Eulexin) Leuprolide (Lupron) Nafarelin (Synarel) Megestrol acetate... [Pg.946]

These three analogues are more metabolically stable than LHRH. Thus, the half-life of nafarelin in monkeys and rats after i.v. administration was four to five times longer than that of LHRH [214], When incubated in monkey plasma, LHRH was readily degraded (f1/2 ca. 2 h), whereas nafarelin was more resistant (tm> 160 h). The metabolism of [14C]nafarelin was also investigated in humans following subcutaneous administration [215]. As shown in Fig. 6.39, the first metabolic steps were cleavage in the 4-5, 5-6, and 7-8 positions. Because of the presence of the 14C-label, the fate of D-2-Nal could be carefully monitored. The same metabolic pattern was observed in the rhesus monkey [216]. [Pg.352]

Fig. 6.39. The structure of LHRH (6.89), leuprolide (6.90), deslorelin (6.91), and nafarelin (6.92). Also shown is the metabolism of nafarelin in humans [215]. Fig. 6.39. The structure of LHRH (6.89), leuprolide (6.90), deslorelin (6.91), and nafarelin (6.92). Also shown is the metabolism of nafarelin in humans [215].
N. I. Chu, R. L. Chan, K. M. Hama, M. D. Chaplin, Disposition of Nafarelin Acetate, a Potent Agonist of Luteinizing Hormone-Releasing Hormone, in Rats and Rhesus Monkeys , Drug Metab. Dispos. 1985, 13, 560 - 565. [Pg.380]

R. L. Chan, M. R. Henzl, M. E. LePage, J. LaFargue, C. A. Nerenberg, S. Anik, M. D. Chaplin, Absorption and Metabolism of Nafarelin, a Potent Agonist of Gonadotrophin-Releasing Hormone , Clin. Pharmacol. Ther. 1988, 44, 275-280. [Pg.380]

Moricizine 50 Morphine 50 Morphine Sul te 50 Motrin 41 MS Contin 50 Mucomyst 12 Mupirocin 50 Myambutol 33 Mycelex 26 Mycifiadin 51 Myciguent 51 Mycobutin 60 Mycolog-ll 77 Mycostatin 53 Mylanta 47 Mysoline 57 Nabumetone 50 Nadolol 50 Nafarelin 50 Nafdl 50 Nafcillin 50 Naftifine 50 Naftin 50... [Pg.81]

Leuprorelin acetate Nafarelin acetate C2H5-NH-Pro-Arg-Leu-D-Leu-Tyr-Ser-Trp-His-5oxo pro NH2-Gly-Pro-Arg-Leu-D-Ala-Tyr-Ser-Try-His-5oxo pro 1... [Pg.345]

Gonadotropin-releasing hormone (GnRH) analogs buserelin acetate goserelin acetate leuprolide acetate nafarelin acetate... [Pg.606]

Nafarelin aoetate Antiendometriotic agent gonadotropin inhibitor... [Pg.459]

Dosage form Two versions of Synarel are available Synarel Nasal Solution for Central Precocious Puberty and Synarel Nasal Solution for Endometriosis. They appear to be the same except for package and labeling. Each 0.5 ounce bottle contains 8 ml Synarel Nasal Solution 2mg/ml (as nafarelin base). Each bottle is supplied with a metered spray pump that delivers 200 pg of nafarelin per spray. [Pg.233]

Drug interactions The label states that no pharmacokinetic-based drug-drug interaction studies have been conducted with Synarel. However, because nafarelin acetate is a peptide that is primarily degraded by peptidase and not by cytochrome P-450 enzymes, drug interactions would not be expected to occur. [Pg.234]

G. Other applications Nafarelin may be an effective contraceptive in women because it suppresses ovulation. Subcutaneous administration of nafarelin is partially effective in suppressing spermato-... [Pg.234]

Nafarelin acetate, gonadotropin-releasing hormone (GnRH) agonist... [Pg.459]

See other pages where Nafarelin is mentioned: [Pg.655]    [Pg.143]    [Pg.558]    [Pg.40]    [Pg.169]    [Pg.197]    [Pg.593]    [Pg.617]    [Pg.594]    [Pg.619]    [Pg.352]    [Pg.33]    [Pg.72]    [Pg.342]    [Pg.342]    [Pg.273]    [Pg.232]    [Pg.232]    [Pg.233]    [Pg.233]    [Pg.234]    [Pg.234]    [Pg.234]   
See also in sourсe #XX -- [ Pg.169 ]

See also in sourсe #XX -- [ Pg.335 , Pg.336 ]

See also in sourсe #XX -- [ Pg.387 ]

See also in sourсe #XX -- [ Pg.342 ]

See also in sourсe #XX -- [ Pg.232 , Pg.233 ]

See also in sourсe #XX -- [ Pg.356 , Pg.385 ]

See also in sourсe #XX -- [ Pg.440 ]

See also in sourсe #XX -- [ Pg.412 , Pg.413 ]

See also in sourсe #XX -- [ Pg.247 , Pg.250 , Pg.250 ]

See also in sourсe #XX -- [ Pg.711 ]

See also in sourсe #XX -- [ Pg.383 ]

See also in sourсe #XX -- [ Pg.493 , Pg.510 ]

See also in sourсe #XX -- [ Pg.642 ]

See also in sourсe #XX -- [ Pg.975 , Pg.976 ]

See also in sourсe #XX -- [ Pg.295 ]

See also in sourсe #XX -- [ Pg.332 , Pg.334 , Pg.484 ]

See also in sourсe #XX -- [ Pg.143 ]

See also in sourсe #XX -- [ Pg.59 ]



SEARCH



Estrogens nafarelin

Nafarelin acetate

Nafarelin dosing

Synarel - Nafarelin acetate

© 2024 chempedia.info