Buserelin acetate

Gonadotropin-releasing hormone (GnRH) analogs buserelin acetate goserelin acetate leuprolide acetate nafarelin acetate... 

A 49-year-old woman developed Graves disease after receiving buserelin acetate for 4 months. 

Kono T, Ishii M, Taniguchi S. Intranasal buserelin acetate-induced pigmented roseola-like eruption. Br J Dermatol 2000 143(3) 658-9. 

Matsubara K, Irie T, Uekama K. Controlled release of the LHRH agonist buserelin acetate from injectable suspensions containing triacetylated cyclodextrins in an oil vehicle. J Control Release 1994 31 173-180. 

SUPRECUR SU PREFACT Shire (UK) (from HMR) Buserelin acetate (100/150 xg buserelin) LHRH analogue, Mr= 1300 BKC, NaCI, NaCit, cit Bottle... 

Uekama, K., Arima, H., Me, T., et al. (1989) Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from the injectable oily preparation utilizing ethylated P-cyclodextrin. J. Pharm. Pharmacol 41 874-876. 

Buserelin acetate reduces the plasma levels of endogenous sex hormones to a castrate level through down-regulation, when administered continuously or daily. These paradoxical and pharmacological effects are utilized in the treatment of endocrine-dependent diseases such as endometriosis and precocious and uterine... 

The nasal administration was shown to be an effective administration route for lipophilic active substances like fentanyl. Moreover, the nasal route has also been used for the systemic administration of small peptides like buserelin acetate, nafarelin acetate and desmopressin, aU of them containing ten or less amino acid residues. However, for these molecules the nasal route forms only a poor non-invasive alternative to injection, since the nasal bioavailability of these peptides is less than 3-5 %. 

Suprecur MP Buserelin acetate Aventis Prostate cancer Marketed... 

Commercially available peptide hormones delivered as nasal spray solutions include Synarel (nafare-lin), Stimate NS (desmopressin), Suprefact (buserelin acetate), and Miacalcin (salmon calcitonin). A list of current drugs in the market, doses, and bioavailability along with a comparative bioavailability profile for oral desmopressin is presented in Table 86.3. 

Buserelin acetate Injection 1 mg/mL, 100 gg metered nasal spray. 

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