N-Nitrosamine carcinogenesis

Hecht, S.S., Approaches to cancer prevention based on an understanding of N-nitrosamine carcinogenesis, Proc. Soc. Exp. Biol. Med., 216, 181, 1997. 

NT087 Hoffmann, D., M. V. Djordjevic, A. Rivenson, E. Zang, D. Desai, and S. Amin. A study of tobacco carcinogenesis. LI. Relative potencies of tobacco-specific N-nitrosamines as inducers of lung tumours in A/J mice. Cancer Lett 1993 71(1-3) 25-30. 

Amin, and R. Hoffmann. A study of tobacco carcinogenesis XLIV. Bioassay in A/] mice of some N-nitrosamines. Cancer Lett 1989 47(1-2) 111-114. 

N-nitrosodialkylamines - nitrosamines - constitute one of the most extensive series of known chemical carcinogens. Most nitrosamines can initiate tumors in at least one animal species, and all animal species which have so far been tested are susceptible to nitrosamine carcinogenesis O, 2 ). 

C. A. Reynolds and C. Thomson, Int. ]. Quantum Chem., Quantum Biol. Symp., 11, 167 (1984). Ab Initio Calculations Relevant to the Mechanism of Chemical Carcinogenesis by N-Nitrosamines. 1. The Nitrosation of Amines. 

Hecht, S. S., 1982, N-nitrosamines in tobacco carcinogenesis, in "Banbury Report 12 Nitrosamines and Human Cancer,"... 

Ohshima, H., Tsuda, M., Adachi, H., Ogura, T, Sugimura, T., Esumi, H. (1991). L-atginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopoly saccharide and interferon-gamma. Carcinogenesis 12, 1217-1220. 

GUO Z, SMITH T J, WANG E, SADRIEH N, MA Q, THOMAS P E and YANG C S (1992) Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabohzing enzymes and nitrosamine metabolism in rats . Carcinogenesis, 13 2205-10. 

Tatematsu M, Miyata Y, Mizutani M, et al. 1977. [Summation effect of N-butyl-n(4-hydroxybutyl)nitrosamine,N-(4-(5-nitro-2-furyl)-2thiazoly) formamide, N-2-fluoroenylacetanide, and 3,3 -dichlorobenzidine on urinary bladder carcinogenesis in rats.] Jarm 68 193-202. (Japanese)... 

Brendler, S.Y., Tompa, A., Hutter, K.F., Pieussmatm, R. Pool-Zobel, B.L. (1992)/n vivo and in vitro genotoxicity of several A-nitrosamines in extrahepatic tissues of the rat. Carcinogenesis, 13,2435-2441... 

Miyata, Y, Fukushima, S., Hirose, M., Masui, T. Ito, N. (1985) Short-term screening of promoters of bladder carcinogenesis in A-butyl-A-(4-hydroxybutyl)nitrosamine-initiated unilaterally ureter-ligated rats. Jpn. J. Cancer Res. (Gann), l, 828-834... 

Swann, PF. Magee, P.N. (1968) Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by A-methyl-A -nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate. Biochem. J., 110, 39-47... 

Shirai, T., Masuda, A., Imaida, K., Ogiso, T. Ito, N. (1988) Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with A -bis(2-hydroxypropyl)nitrosamine. Jpn. J. Cancer Res., 79,460 65... 

Okajima, E., Tsutsumi, M., Ozono, S., Akai, H., Denda, A., Nishino, H., Oshima, S., Sakamoto, H., and Konishi, Y. 1998. Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4hydroybutyl) nitrosamine initiation. Jpn. J. Cancer Res. 89, 22-26. 

Hagiwara A, Tamano S, Ogiso T, et al. 1990. Promoting effect ofthe peroxisome proliferator, clofibrate, but not di( 2-ethyl hexyl) phthal ate, on urinary bladder carcinogenesis in F344 rats initiated by n-butyl-n-(4-hydroxybutyl)nitrosamine. Jpn J Cancer Res 81 1232-1238. 

Sakata, T., Shirai, T., Fukushima, S., Hasegawa, R., and Ito, N., Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine in F344 rats, Gann, 75, 950, 1984. 

Hecht, S.S., C.B. Chen, N. Hirota, R.M. Omaf, T.C. Tso, and D. Hoffmann A stndy of tobacco carcinogenesis. XVI. Tobacco-specific nitrosamines Formation from nicotine in vitro and dnring curing of tobacco and carcinogenicity in Strain-A mice J. Natl. Cancer Inst. 60(1978)819-824. 

Rivenson, and S.S. Hecht A-Nitrosamines in human carcinogenesis in Nitrosamines and human cancer, Banbury Report 12, edited by P.N. Magee, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1982) 211-225. 

Mitacek, E.J., K.D. Brunnemann, D. Hoffmann, T. Limsila, M. Suttajit, N. Martin, and L.S. Caplan Volatile nitrosamines and tobacco-specific nitrosamines in the smoke of Thai cigarettes A risk factor for lung cancer and a suspected risk factor for liver cancer in Thailand. Carcinogenesis 20 (1999) 133-137. 

Herrold, K.M. and L.J. Dunham Effects of subcutaneous injection of dimethylnitrosamine in the Syrian hamster Proc. Am. Assoc. Cancer Res. 4 (1963) 28. Hoffmann, D., K.D. Bmnnemann, J.D. Adams, A. Rivenson, and S.S. Hecht A-Nitrosamines in human carcinogenesis in Nitrosamines and human cancer, edited by P.N. Magee, Banbury Report 12, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1982) 211-226. 

Motohashi, N., K. Kamata, and R. Meyer Chromatographic techniques used to determine benz[c] acridines in environmental samples J. Chromatog. 643 (1993) 1-10. Mumford, J.L., D.B. Harris, and K. Williams Indoor air sampling and mutagenicity studies from unvented coal combustion Environ. Sci. Tech. 21 (1987) 308-311. Murphy, S.E. and R. HeUbrun Effect of nicotine and tobacco-specific nitrosamines on the metabolism of A -nitrosonomicotine and 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone by rat oral tissue Carcinogenesis 11 (1990) 1663-1666. 

S. V. Bhide. 1989. Carcinogenicity studies on the two tobacco-specific A-nitrosamines, N -nitrosonornicotine and 4-(methylnitrosa-mino)-1 -(3-pyridyl)-1 -butanone. Carcinogenesis 70(11) 1977-2002. 

Hashimoto, Y., In Vitro and In Vivo Effects of Nitrosamine and Urea on Rat Urinary Bladder Epithelial Cells. In T.J. Slaga, A. Sivak, R.K. Boutwell, eds. "Carcinogenesis - A Comprehensive Survey - Volume 2", Raven Press, New York, N.Y., 1978, 443-448. 

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