N-methyl scopolamine

N-butyl-scopolamine (BuS) cimetropium (Cim) ipratropium (Ipra) N-methyl-scopolamine (MeS)... 

Chuang DM, Gao X-M, Paul SM N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells. Mol Pharmacol 42 210-216, 1992 Chugh Y, Saha N, Sankaranarayanan A, et al Enhancement of memory retrieval and attenuation of scopolamine-induced amnesia following administration of S-HTj antagonist ICS 205-930. Pharmacol Toxicol 69 105-106, 1991 Ciraulo DA, Jaffe JH Tricyclic antidepressants in the treatment of depression associated with alcoholism. Clin Psychopharmacol 1 146, 1981 Ciraulo DA, Barnhill JG, Jaffe JH Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers. Pharmacol Ther 43 539-548, 1988... 

Methylscopolamine is a QTA obtained by N-methylation of scopolamine (Fig. 1). It exhibits non-selective antimuscarinic activity and is used as adjunctive therapy for the treatment of peptic ulcer, to treat nausea and vomiting due to motion sickness and for the management of irritable bowel syndrome [75], The tritiated form of methylscopolamine is often used in in vitro MR binding assays to investigate receptor affinity and competition by other agents [76],... 

There is less information about the metabolism of other tropane alkaloids but for those that are esters (e.g. hyoscyamine, scopolamine) hydrolysis of the ester bond takes place to some extent, yielding bases, which may be further transformed [45, 46], Rabbit serum has been found to have esterases that are relatively specific for esters of tropic acid, and this may account for the ability of rabbits to feed with impunity on leaves of Atropa belladona [47]. Mice transform released tropic acid to a glucuronide [48]. Oxidation also occurs, both in rats and humans, with the production of N-oxides and oxidative removal of the N-methyl group to make nor-derivatives [45,46]. 

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