Mutagenic analysis

COMMONER, B VITHAYATHIL, A. J. and DOLARA, P. Mutagenic Analysis of Complex Samples of Air Particulates, Aqueous Effluents, and Foods. ibid. 

Commoner, B., A. J. Vithayathil, and P. Dolara, Mutagenic Analysis of Complex Samples of Aqueous Effluents, Air Particulates, and Foods, in Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (M. D. Waters, S. Nesnow, J. L. Huisingh, S. Sandhu, and L. Claxton, Eds.), pp. 529-570, Plenum, New York, 1979. 

De Pollok, F. S., V. P. Aneja, T. J. Hughes, and L. D. Claxton, Chemical and Mutagenic Analysis of Volatile Organic Compounds in Raleigh Air Samples at Three Different Elevations before, during, and after Hurricane Gordon, Chemosphere, 35, 879-893 (1997). 

For the mutagenicity analysis a decision-point approach to testing for carcinogenicity is used(From Casarett and Doull, Toxicology 3rd Edition)... 

J. A. Alvarez, T. Ferain, D. Garmyn, P. Hols, A. Cortes, A. R. Clarke, J. J. Holbrook, and J. Delcour, D-2-Hydroxy-4-methylvalerate dehydrogenase from Lactobacillus delbrueckii subsp. bulgaricus II. Mutagenic analysis of catalytically important residues, Eur. J. Biochem. 1997, 244, 213-219. 

D Angelo DD, Eubank JJ, Davis MG, Dom II GW. Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling. JBiol Chem 1996 271 6233-40... 

The mechanistic relevance of this reaction partitioning concept was again illustrated by our stmctural and mutagenic analysis of the iterative THNS... 

Cirilli, M., Zheng, R., Scapin, G., and Blanchard, J.S. (2003) The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry 42, 10644-10650. 

Mayer BJ, Hanafusa H. 1990. Mutagenic analysis of the v-crk oncogene requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation. J Virol 64(8) 3581-3589. 

C. Chriswell, B. A. Glatz, J. S. Fritz, and H. J. Svec, Mutagenic analysis of drinking water samples. Presented at the Symposium on Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures, Williamsburg, Virginia, February 21-23, 1928, pp. 477-494, EPA-600/9-78-027, September 1978. 

Guanine also forms a number of adducts or lesions with environmental mutagens. Analysis of a range of mutagenic lesions has been examined, in particular the cyclo-derivative (48) as well as the adenine derivative and carboxymethylated lesions by next generation sequencing techniques. The assay validated quantitatively how such lesions compromised the... 

The analysis of combustion products presents problems of complexity similar to that of feedstock and raw fuel analysis. A highly complex matrix of aliphatic material often exists (as unburnt fuel in the combustion exhaust), whilst the species of interest, for example, carcinogens or mutagens are often at very low concentrations. A classic example of multidimensional GC is its use in the analysis of flue-cured tobacco essential oil condensate. 

Waters MD, Stack HF, Jackson MA, et al. 1994. The performance of short-term tests in identifying potential germ cell mutagens A qualitative and quantitative analysis. Mutat Res 341 109-131. 

Venegas W, Zapata I, Carbonell E, et al. 1998. Micronuclei analysis in lymphocytes of pesticide sprayers from Conception, Chile. Teratog Carcinog Mutagen 18 123-129. 

Young SS, Gombar VK, Emptage MR, Cariello NE, Lambert C. Mixture deconvolution and analysis of Ames mutagenicity data. Chemo Intell Lab Sys 2002 60 5-22. 

The COMPACT (computer-optimized molecular parametric analysis of chemical toxicity) procedure, developed by Lewis and co-workers [92], uses a form of discriminant analysis based on two descriptors, namely, molecular planarity and electronic activation energy (the difference between the energies of the highest occupied and lowest unoccupied molecular orbitals), which predict the potential of a compound to act as a substrate for one of the cytochromes P450. Lewis et al. [93] found 64% correct predictions for 100 compounds tested by the NTP for mutagenicity. 

Such an analysis could, in turn, provide clues as to which specific DNA lesions generated by these agents were mutagenic. 

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