Muscle factors affecting

Intramuscularly administered products typically form a depot in the muscle mass from which the drug is slowly absorbed. The peak drug concentration is usually seen within 1-2 hours. Factors affecting the drug-release rate from an IM depot include the compactness of the depot (the less compact and more diffuse, the faster the release), the rheology of the product, concentration and particle size of drug in the vehicle, nature of the solvent or vehicle, volume of the injection, tonicity of the product, and physical form of the product. 

Krebs, E.G., Graves,D.J. and Fischer, E.H. Factors affecting the activity of muscle phosphorylase kinase (1959) J. Biol. Chem. 2867-2873... 

Regenstein, J.M. and Rank Stamm, J. 1979. Factors affecting the sodium chloride extractability of muscle proteins from chicken breast, trout while, and lobster tail muscles./. Food Biochem. 4 191-204. 

One death in an adult female due to acute intravasation of barium sulfate during a barium enema was found in the literature. Direct entry of barium sulfate into the circulatory system apparently resulted in cardiorespiratory failure (Cove and Snyder 1974). Acute parenteral administration of barium compounds to animals has resulted in death. Rate of administration, total dose, species, and individual differences are all factors affecting the ability of barium and its compounds to cause death. Major symptoms leading to death are hypokalemia (Jalinski et al. 1967 Roza and Berman 1971 Schott and McArdle 1974), muscle paralysis (Roza and Berman 1971 Schott and McArdle 1974), cardiorespiratory failure (Cove and Snyder 1974 Roza and Berman 1971), and convulsions (Segreti... 

As shown in Fig. 76, exercise-related acute renal failure is classified into two types myoglobinuric acute renal failure and non-myoglobinuric acute renal failure. The latter is represented by ALPE. The grade of rhabdomyolysis and the type/grade of muscle fibers affected are shown in Fig. 76. Pathogenetic factors for ALPE should be investigated in the future. 

Blom, P. C., Vollestad, N. K., and Costill, D. L. (1986). Factors affecting changes in muscle glycogen concentration during and after prolonged exercise. Acta Physiol., Suppl. 128(556), 67-74. 

H17. Hultin, H. O., and Westort, C., Factors affecting the distribution of lactate dehydrogenase between particulate and non-particulate fractions of homogenized skeletal muscle. Arch. Biochem. Biophys. 117, 523-533 (1966). 

Cull-Candy, S.G. Miledi, R. "Factors affecting the channel kinetics of glutamate receptors in locust muscle fibres" Sattelle, D.B., Hall, L.M., Hildebrand, J.G. Eds. Receptors for neurotransmitters, hormones and pherhomones in insects, Elsevier, New York 1980, p.161-173. 

Stanley (1983) stated that many researchers now believe the major structural factors affecting meat texture are associated with connective tissues and myofibrillar proteins. Therefore, he suggested that these structures merit particular attention. He concluded that two other components, muscle membranes and water, also deserve consideration, not because of their inherent physical properties, but rather as a result of the indirect influence they have on the physical properties. It should be noted that sarcoplasmic... 

Davis HL, Whalen RG, Demeneix BA. Direct gene transfer into skeletal muscle in vivo factors affecting efficiency of transfer and stability of expression. Hum Gene Ther 1993 4 151-159. 

Factors that affect texture include moisture content, composition, variety or species, pH, product history (maturation or age), and sample dimensions. Texture is also dependeut on the method of dehydration and pretreatments. Purslow [55] stated that meat texture is affected by the structure of the solid matrix. He coucluded that it is important to have a fundamental understanding of the fracture behavior of meat and how it relates to the structure of the material. Stanley [83] stated that many researchers now believe that the major structural factors affecting meat texture are associated with connective tissues aud myofibrillar proteins. Moreover, two other components muscle membranes and water also deserve consideration not because of their inherent physical properties, but rather as a result of the indirect influence they have on the physical properties. It should be noted that sarcoplasmic proteins may be important for the same reason, although little information on their role is available. He suggested that these structures merit particular attention. 

Clayton, W. E. 1984. Humirhty Factors Affecting Storage and HandBng of Fertilizers, IFDC-P-5, International Fertilizer Devcbpment Center, P.O. Box 2040, Muscle Shoals, AL, U.S.A. 

Effects of exercise. Factors affecting muscle function have been... 

Factors Affecting Insulin Secretion Structure and Synthesis of Insulin Insulin Transport and Breakdown Metabolic Effects of Insulin Carbohydrate Metabolism 510 Muscle Liver... 

Loiselle DS, Gibbs CL (1983) Factors affecting the metabolism of resting rabbit papillary muscle. Pflugers Archiv 396 285-291... 

The human body has a limited ability to resist injury from physical agents, by virtue of the innate strength of such tissues as skin, muscle, and bone. However, people whose tissues have been previously weakened by poor nutrition may be badly hurt by even the mildest of injurious agents. For example, older people may have bones which are easily broken, due to long subsistence on a diet low in calcium, vitamin D, and/or protein. Some of the other ways in which nutritional factors affect susceptibility to injury follow. 

APPLEMAN, M. M., BIRNBAUMER, L. and TORRES, H. N. (1966) Factors affecting the activity of muscle glycogen synthetase. III. 

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