Channel kinetics

Electrophysiological studies (mainly using voltage-clamp and patch clamp) revealed the essential properties of the sodium channels kinetics of channel gating and selective ion permeation. Sodium channels are... 

Kraus RL, Sinnegger MJ, Glossmann H, Hering S, Striessnig J (1998) Familial hemiplegic migraine mutations change alphalA Ca2+ channel kinetics. J Biol Chem 273 5586-5590. 

Turner, P.R., Schultz, R., Ganguly, B., and Steinhardt, R.A., 1993, Proteolysis results in altered leak channel kinetics and elevated free calcium in mdx muscle, J Membr Biol, 133, pp 243-251. 

Nakano, A. Xie, Q. Mallen, J. V. Echegoyen, L. Gokel, G. W., (1990) Synthesis of a membrane-insertable, sodium cation conducting channel kinetic analysis by dynamic sodium-23 NMR J. Am. Chem. Soc. 112, 1287-1289. 

Dependence on Ca2+ Sensing Latency Times, Ca2+ Channel Kinetic Parameters, and Channel Clustering... 

In the classical book [4], the distinct models dealing with ion channel kinetics are extensively discussed. One of the important results is the connection established between fractal scaling and stochastic modeling. Based on experimental data, Liebovitch et al. [394] assessed the dependence of the effective kinetic constant ka on the sufficient time scale for detection tG by a fractal scaling relationship ... 

Liebovitch, L., Fischbarg, J., and Koniarek, J., Ion channel kinetics A model based on fractal scaling rather than multistate Markov processes, Mathematical Biosciences, Vol. 84, No. 1, 1987, pp. 37-68. 

THE AVAILABILITY OF A REACTION CHANNEL. KINETIC VS. THERMODYNAMIC CONTROL... 

Tang YH, Stephenson JL, Othmer HG. Simplification and analysis of models of calcium dynamics based on IPs-sensitive calcium channel kinetics. Biophys. J. 1996 70 246-263. 

There are (L/2nfd ki states in the range d ki about k,. Many different final states belong to the same energy channel, defined by the channel kinetic energy but have different directions given by the polar angles... 

Adelsberger H, Quasthoff S, Grosskreutz J, Lepier A, Eckel F, Lersch C. The chemotherapeutic oxahplatin alters voltage-gated Na(+) channel kinetics on rat sensory neurons. Eur J Pharmacol 2000 406(l) 25-32. 

Isom Yes, in S2 cells j lC121W does not cause aggregation, although it is expressed (Loukas et al 2001). In mammalian cells and oocytes we can see modulation of the channel kinetics, but we have to put in a high concentration of RNA. I think it is an affinity issue, so we can push the association if we add a lot (Loukas et al 2001). In the original paper (Wallace et al 1998) they showed no modulation of the channel, and I think this is true at that concentration. If you put in a high concentration, you can make it act like ) 1. 

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