Murine air pouch

Angiogenesis Prophylactic treatment with ATL-1 protected against angiogenesis and CD-31 expression in a murine air pouch model of angiogenesis ATL-1 potently inhibits endothelial cell proliferation ATL-1 inhibits VEGF-induced endothelial cell chemotaxis Fierro et al 2002 Fierro et al 2003... 

Figure 5 Schematic of the murine air-pouch in vivo chemotaxis model. BALB/c mice were anesthetized, their backs were shaved, and the shaved sites were injected with 3 ml of sterile air under the skin. This was repeated on days 2, 4, and 5, and 1 ml of air was injected to create the air pouch.

Resolvins (Rv) are derivatives of EPA and/or DHA and are now well-established as exhibiting anti-inflammatory or pro-resolving properties. They were first identi-hed in a murine air pouch model by Serhan in 2000 (Serhan et al. 2000), and since then have been both applied and detected in various animal inflammatory disease models (i.e., colitis, ischemia-reperfusion injury, wound healing) and human nutritional intervention/disease studies (Kasuga et al. 2008 Bento et al. 2011 Norling et al. 2011 Giera et al. 2012 Mas et al. 2012). 

Wooley PH, Morren R, Andary J, Sud S, Yang S-Y, Mayton L, et al. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials 2002 January 23(2) 517-26. 

Yang S, Wu B, Mayton L, Evans CH, Robbins PD, Wooley PH. IL-lRa and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. InflammRes 2002 July,51(7) 342-50. 

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