Multiple sclerosis , chemokine expression

Simpson JE, Newcombe J, Cuzner ML, Woodroofe MN (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J Neuroimmunol 84 238-249 Simpson J, Rezaie P, Newcombe J, Cuzner ML, Male D, Woodroofe MN (2000) Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue. J Neuroimmunol 108 192-200... 

Sorensen TL, Sellebjerg F (2001) Distinct chemokine receptor and cytokine expression profile in secondary progressive MS. Neurology 57 1371-1376 Sorensen TL, Tani M, Jensen J, Pierce V, Lucchinetti C, Folcik VA, Qin S, Rottman J, Sellebjerg F, Strieter RM, Frederiksen JL, Ransohoff RM (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103 807-815... 

CXCR3 is expressed in the immnne system as two isoforms, CXCR3-A and CXCR3-B. It is an important chemokine receptor associated with varions inflammatory neurodegenerative diseases (e.g. multiple sclerosis) and other models of nenronal injury as reviewed by (Liu et al. 2005). 

Simpson J, Rezaie P, Newcombe J, et al. Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue. J Neuroimmunol 2000 108 192-200. 

M19. Misu, T., Onodera, H., Fujihara, K., Matsushima, K., Yoshie, O., Okita, N., Takase, S., and Itoyama, Y., Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis Imbalance of Thl/Th2-associated chemokine signaling. J. Neuroimmunol. 114, 207-212 (2001). 

Simpson JE, Newcombe J, Cuzner ML, Woodrofe MN (1998) Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis. J Neuroimmunol 84 238-249. 

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