Domain multi

Adaptor proteins are multi-domain proteins (Fig. 1) that interact with components of signaling pathways [1]. As a consequence of these interactions, adaptor proteins are able to regulate signaling events within the cell, providing spatiotemporal control and specificity, and influencing how a cell responds to a particular stimulus. 

Page, A.P. and Winter, A.D. (1998) A divergent multi-domain cyclophilin is highly conserved between parasitic and free-living nematode species and is important in larval muscle development. Molecular and Biochemical Parasitology 95, 215-227. 

The gene nompA encodes a multi-domain extracellular protein that is expressed by support cells that cradle the mechanically sensitive neuron [9]. NompA is localized to the dendritic cap, which is covers the mechanically sensitive outer segment of the neuron. NompA is a good candidate for a protein that couples mechanically sensitive channels to external stimuli. 

The experimental approach used to mechanically stretch a chromatin fiber with the AFM is depicted schematically in Fig. 8a, and some example curves obtained with native chicken erythrocyte chromatin fibers are presented in Fig. 8b. These curves exhibited a saw-tooth pattern, similar to the patterns obtained upon stretching of multi-domain proteins like titin [71] or tenascin [72] (Fig. 8c). Each of... 

Gompounds that inhibit Akt-1 are of increasing interest as possible oncology therapeutics [59]. Akt-1 is a multi-domain protein that is known to be activated after binding of its pleckstrin homology (PH) domain to its endogenous target. A report from researchers at Merck indicates that their Akt-1 inhibitor does... 

Conditions which promote multi-domainic goethites are high ionic strength (either [KOH] or salt) and also low synthesis temperature (<40°C). In alkaline solutions, multi-domainic character decreases and domain width increases as Al substitution increases to Al/(Fe-i-Al) of 0.15, whereas at Al/( Al-nFe) >0.15 single domain crystals result (Schulze Schwertmaim, 1984 Mann et al., 1985). Multidomainic goethites can recrystallize to single domain crystals as a result of hydrothermal treatment at 125-180 °C (Fig. 4.9) (Schwertmann et al., 1985). 

Fig. 7.12 Left Hysteresis loops of MD (top) and SD magnetite (bottom) (modified from Dunlop, 1990, with permission). Right The ratio Jrs/Js as a function of the ratio of Hcr/Hc. The fields for single domain (SD), pseudo-single domain (PSD), and multi domain (MD) particles are given for magnetite.

Fig. 7.13 The size and shape dependence of superparamag-netic (SP), multi-domain (MD) and single-domain particles (SD) as a function of the axial shape ratio The times x refer to relaxation times of 4 10 a and 100 s (from Butler, Banerjee, 1975, with permission).

Dong H, Paramonov SE, Aulisa L, Bakota EL, Hartgerink JD. Self-assembly of multi-domain peptides balancing molecular frustration controls conformation and nanostructure. J Am Chem Soc 2007 129 12468-12472. 

Direct evidence for inter-domain dynamics in multi-domain proteins 136... 

RDC methods used to probe the structural dynamics between relatively large molecular fragments such as domains in multi-domain proteins can be... 

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