Mucus secreting cells

Behrens, I., Stenberg, P., Arturs-son, P., Kissel, T., Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells, Pharm. 

Lack of mucus secreting cells resulting in absence of a mucus layer... 

Coconnier, M. H., Klaenhammer, T. R., Kernels, S., Bernet, M. F., and Servin, A. L. (1992). Protein-mediated adhesion of Lactobacillus acidophilus BG2F04 on human enterocyte and mucus-secreting cell lines in culture. Appl. Environ. Microbiol. 58,2034-2039. 

The major effects of retinoic acid is evidently through regulation of transcription (Chapter 28). In developing lungs retinoic acid promotes the transformation of undifferentiated epithelial cells into mucus-secreting cells.dd... 

Mucosa Membrane containing mucus-secreting cells. 

This is a simple mucus-secreting cell which does not undergo division. Mucus secreted by the goblet cells makes the intestinal surface viscid, a condition which must greatly assist the close adhesion of tapeworm strobila. Adhesion to the mucosa is probably essential to the normal nutritional efficiency of cestodes, but the degree of dependence may vary widely with species. At least in E. granulosus, as demonstrated by experiments in vitro (Fig. 10.6, p. 271), contact with a solid proteinaceous substrate appears to be essential for strobilisation. Rather surprisingly, this requirement is not essential for E. multilocularis, which strobilates in vitro in... 

Secretory cells occur in most epithelial surfaces e.g., sweat gland cells in the skin and mucus-secreting cells in the intestine and respiratory tract. 

B12. B anger, L. F., Comparison between different histochemical and histo-physical techniques as applied to mucus secreting cells. Ann. N. Y. Acad. Sci. 106, 364-378 (1963). 

A FIGURE 6-4 Principal types of epithelium. The apical and basolateral surfaces of epithelial cells exhibit distinctive characteristics, (a) Simple columnar epithelia consist of elongated cells, including mucus-secreting cells (in the lining of the stomach and cervical tract) and absorptive cells (in the lining of the small intestine), (b) Simple squamous epithelia, composed of thin cells, line the blood vessels (endothelial cells/endothelium) and many body cavities, (c) Transitional epithelia, composed of several layers of cells with different shapes, line certain cavities subject to expansion and contraction (e.g., the urinary bladder). 

In myoepithelial components SlOO +, Actin +, Calponin +, Vimentin +, GFAP +, CK5/6 +, CK14 + In mucus-secreting cells CK8 +, CK17 +, CK18 +, CK19 +, EMA+, CK7 +/-... 

Reduction of the disulfide bond in the thiol-rich environment, resulting in the release of the entrapped protein, was also the working principle of another intracellular protein delivery system. The DDS was based on linear polyamidoamines (PAAs) that formed a PEC with negatively charged human serum albumin (HSA). The PEC showed mucoadhesive properties and released the immobilized HSA under intracellular conditions due to the cleavage of the disulfide bonds, while the complex was stable under extracellular conditions. This resulted in enhanced uptake by exposed human-derived intestinal Caco-2/TC7 cells and HT29-MTX mucus/ secreting cells. 

Wlodarska M, Thaiss CA, Nowarski R, et al. NLRP6 Inflammasome Orchestrates the Colonic Host—Microbial Interface by Regulating Goblet Cell Mucus Secretion. Cell. 2014 156 1045-1059. 

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