Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Mucosa enhancement

Immunoglobulin M Virtually all PBC patients show increased serum IgM values. This IgM differs remarkably from the IgM of healthy persons. Elevated monomeric IgM was also detected in the skin, in hepatocytes and in the intestinal mucosa. Enhanced IgM serum values were likewise determined in relatives of PBC patients, (see 4.3.1) However, there was no correlation between IgM serum values and the tissue level values, cholestasis or morphological changes. Progressive PBC courses result in augmented IgG as well. [Pg.644]

Permeation enhancers are used to improve absorption through the gastric mucosa. Eor example, oral dehvery of insulin (mol wt = 6000) has been reported from a water-in-oH- emulsion containing lecithin, nonesterified fatty acids, cholesterol [57-88-5], and the protease inhibitor aprotinin [9087-70-1] (23). [Pg.141]

Ando T, Hatsushika K, Wako M, Ohba T. Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K. Luo J, Wyss-Coray T, Nakao A Orally administered TGF-P is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol 2007 120 916-923. [Pg.42]

It has the ability to cross the placenta and therefore provides a major line of defence against infection for the newborn. This can be reinforced by transfer ofcolostral IgG across the gut mucosa of the neonate. It diffuses readily into the extravascular spaces where it can act in the neutralization of bacterial toxins and can bind to microorganisms enhancing the process of phagocytosis (opsonization). This is due to the presence on the phagocytic cell surface of a receptor for Fc. [Pg.290]

Davies, G.R., Simmonds, N.J., Stevens, T.R.J., Grandison, A. and Rampton, D.S. (1991). Enhanced production of reactive oxygen species by gastric mucosa infected with Helicobacter pyirri. Gut 32, A564. [Pg.162]

Enhancing the supportive structures underlying the urethral mucosa... [Pg.809]

Phenolphthalein, like anthraquinones and other irritant phenolic compounds, is a stimulant laxative Colonic peristalsis is increased by stimulation of sensory nerve endings in the mucosa of the intestine. Phenolphthalein also enhances entrance of water and salts into the bowel... [Pg.236]

While there are limitations associated with the use of an in vitro permeability model for assessing the transport of compounds across the buccal mucosa, it can still be useful in assessing and comparing the permeability of compounds under different conditions, such as pH, temperature, and osmolarity, which provide valuable information on the mechanisms involved in drug transport. Additionally, the preliminary effects of potential chemical penetration enhancers or formulation excipients may be assessed, and these may provide a substantial rationale for subsequently assessing the effect of these agents in man. [Pg.102]

The buccal mucosa does serve as an alternative route for administering compounds systematically however, to ensure particular compounds are candidates for delivery across this biological tissue, preclinical screening is essential. While in vivo human permeability studies are ideal, due to their costs and associated issues, it is necessary to perform such screening in vitro. Assessment of compound permeability across porcine buccal mucosa has been widely used and can provide the preclinical biopharmaceutical scientist with much information relating to permeability, routes of transport, and effects of various chemical penetration enhancers. [Pg.103]

Hansen LB, Christrup LL, Bundgaard H (1992) Enhanced delivery of ketobemi-done through porcine buccal mucosa in vitro via more lipophilic ester prodrugs. Int J Pharm 88 237-242... [Pg.105]

Kurosaki Y, Hisaichi S, Nakayama T, Kimura T (1989a) Enhancing effect of l-dodecylazacycloheptan-2-one (Azone) on the absorption of salicylic acid from keratinized oral mucosa and the duration of enhancement in vivo. Int J Pharm 51 47-54... [Pg.106]

Kurosaki Y, TakatoriT, KitayamaM, Nakayama T, Kimura T (1988b) Application of propranolol to the keratinized oral mucosa Avoidance of first-pass elimination and the use of 1 -dodecylazacycloheptan-2-one (Azone) as an absorption enhancer of bioadhesive film-dosage form. J Pharmacobiodyn 11 824—832... [Pg.106]

Kurosaki Y, Hisaichi SI, Hong LZ, Nakayama T, Kimura T (1989b) Enhanced permeability of keratinized oral-mucosa to salicylic acid with 1 -dodecylazacycloheptan-2-one (Azone) In vitro studies in hamster cheek pouch. Int J Pharm 49 47-55... [Pg.106]

Senel S, Kremer MJ, Kas S, Wertz PW, Hincal AA, Squier CA (2000) Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. Biomaterials 21 2067-2071... [Pg.108]

Senel S, Hoogstraate AJ, Spies F, Verhoef JC, Bos-van Geest A, Junginger HE, Bodde HE (1994) Enhancement of in vitro permeability of porcine buccal mucosa by bile salts Kinetic and histological studies. J Control Release 32 45-56... [Pg.108]

Shin SC, Kim JY (2000) Enhanced pemeation of triamcinolone acetonide through the buccal mucosa. Eur J Pham Biopham 50 217-220... [Pg.108]

See other pages where Mucosa enhancement is mentioned: [Pg.201]    [Pg.201]    [Pg.155]    [Pg.489]    [Pg.493]    [Pg.227]    [Pg.16]    [Pg.121]    [Pg.525]    [Pg.166]    [Pg.167]    [Pg.190]    [Pg.25]    [Pg.148]    [Pg.225]    [Pg.1519]    [Pg.537]    [Pg.220]    [Pg.351]    [Pg.395]    [Pg.231]    [Pg.266]    [Pg.550]    [Pg.171]    [Pg.29]    [Pg.97]    [Pg.97]    [Pg.160]    [Pg.9]    [Pg.234]    [Pg.196]    [Pg.1216]    [Pg.278]    [Pg.95]    [Pg.98]    [Pg.99]   
See also in sourсe #XX -- [ Pg.196 ]



SEARCH



Absorption enhancers mucosa

An Artificial Olfactory Mucosa for Enhanced Complex Odour Analysis

Buccal mucosa permeability enhancing

Mucosa

Nasal mucosa permeation enhancers

© 2024 chempedia.info