Mooring sequence

ACF recognizes the flexible nucleotides of the mooring sequence and recruits APOBECI... 

In the early 1990s, Moore et al. reported the syntheses of a tremendous variety of meffl-connected PAMs [5 b, 36]. They recognized that the structural rigidity of systems like 8 could be useful in supramolecular chemistry. The convergent, stepwise approach of linear oligomeric phenylacetylene sequences developed in the Moore laboratory permitted absolute control over chain length, order of... 

An impressive achievement of this strategy has been the construction of three-dimensional structures. Utilizing branched phenylacetylene sequences, double cyclization yielded macrobicyclic arrays 54 and 55 [43]. The zenith of Moore s approach is macrotricycle 56, a freely hinged system with a sizable 36xl2xl2A molecular cavity [44]. 

Wang, Y., Moore, M., Levinson, H.S., Silver, S., Walsh, C., and Mahler, I., Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance, J Bacteriol, 171 (1), 83-92,1989. 

Lutz, S., Ostermeier, M., Moore, G.L. et al. (2001) Creating multiple-crossover DNA libraries independent of sequence identity. Proceedings of the National Academy of Sciences of the United States of America, 98, 11248-11253. 

Becker, J.E., Moore, R.E. and Moore, B.S. (2004) Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster molecular basis for imine macrocyclization. Gene, 325, 35 42. 

Britton, C., Moore, C., Gilleard, J.S. and Kennedy, M.W. (1995) Extensive diversity in repeat unit sequences of the cDNA encoding the polyprotein antigen/ allergen from the bovine lungworm Dictyocaulus vivipams. Molecular and Biochemical Parasitology 72, 77-88. 

W. H. Slein, and S. Moore The sequence of amino acids in bovine pancreatic rilwimclease Revisions and confirmations. Journ. Biol. Chem. 238, 227 -234 (1963). 

Zhang JS, Moore JS, Xu ZF, Aguirre RA (1992) J Am Chem Soc 114 2273-2274 Nanoarchitectures 1. Controlled synthesis of phenylacetylene sequences... 

Oh, K. Jeong, K.-S. Moore, J. S. m-Phenylene ethynylene sequences joined by imine linkages Dynamic covalent oligomers. J. Org. Chem. 2003, 68, 8397-8403. 

Zhao, D. Moore, J. S. Folding-driven reversible polymerization of oligo (m-phenylene ethynylene) imines Solvent and starter sequence studies. Macromolecules 2003, 36,2712-2720. 

Moore, J. S. Zimmerman, N. W. Masterpiece copolymer sequences by targeted equilibrium-shifting. Org. Lett. 2000, 2, 915-918. 

ANFINSEN, CHRISTIAN B. (1916-1995). An American biochemist who won the Nobel prize for chemistry- in 1972 for his work on ribonuclease, especially concerning the connection between the amino acid sequence and die biologically active conformation. He shared the Nobel prize with Stanford Moore and William H. Stein. His doctorate was granted from Harvard. 

Ribonucleases are a widely distributed family of en-zymes that hydrolyze RNA by cutting the P—O ester bond attached to a ribose 5 carbon (fig. 8.12). A good representative of the family is the pancreatic enzyme ribonuclease A (RNase A), which is specific for a pyrimidine base (uracil or cytosine) on the 3 side of the phosphate bond that is cleaved. When the amino acid sequence of bovine RNase A was determined in 1960 by Stanford Moore and William Stein, it was the first enzyme and only the second protein to be sequenced. RNase A thus played an important role in the development of ideas about enzymatic catalysis. It was one of the first enzymes to have its three-dimensional structure elucidated by x-ray diffraction and was also the first to be synthesized completely from its amino acids. The synthetic protein proved to be enzymatically indistinguishable from the native enzyme. 

Stanford Moore Rockefeller Univ., amino acid sequence of lysozyme... 

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