Monoamine oxidase comparative studies

In an early study, Insel et al. [1983b] compared the efficacy of CMI with that of clorgiline, a monoamine oxidase-A inhibitor, in a controlled crossover study of patients with OCD. Although CMl was effective, patients on clorgiline did not improve at all. Vallejo et al. [1992] conducted a controlled clinical trial of the efficacy of CMl and phenelzine in 30 patients with OCD. The authors reported improvement in both groups however, the lack of a placebo control and the small size of the study groups limit the applicability of these findings. Further studies on the therapeutic role of monoamine oxidase inhibitors in OCD, especially in OCD with comorbid panic disorder, are warranted. 

A collaborative VA study (364) found that the addition of imipramine or a monoamine oxidase inhibitor to CPZ did not benefit chronic psychotic patients any more than CPZ alone. Further, the addition of an amphetamine was slightly harmful. This finding has since been replicated in several studies on apathetic schizophrenic patients (365). A study of chronic ambulatory schizophrenics compared amitriptyline plus perphenazine with perphenazine alone ( 366). While they found the combination slightly better in ameliorating depressive symptoms, it was at the cost of a slight increase in patients thought disorder. 

Rabkin J, Quitkin F, Harrison W, et al. Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study. J din Psychopharmacol 1984 4 270-278. 

ECT is superior in efficacy when compared with placebo, sham ECT, and active drug therapy. Upon the introduction of effective pharmacotherapy for severe depression, the relative efficacy of drug versus ECT was frequently studied. Our review of the relevant literature led to an extrapolation of the data from selected studies (primarily class I or II designs) for a quantitative analysis of the efficacy of ECT versus other treatments for an acute depressive episode ( 53). The comparisons with ECT included simulated (or sham) ECT, placebo, the standard tricyclic antidepressants, and the monoamine oxidase inhibitors [ Table 8-1 (54, 55, 56, 57, 58 and 59), Table 8 2 (0g 6i 62 and 63), Table 8-3 (56, 61, 62, 63, 64, 65 and 66), and Table 8-4 (55, 60, 61, 62 and 63)]. We also compared the relative efficacy of the bilateral versus the UNID forms of administration [Table 8-5 (42, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77 and 78)]. A meta-analysis was... 

A study comparing monoamine oxidase activity between Japanese and Caucasian livers used rizatriptan as the model substrate (Iwasa et al., 2003). The Japanese livers were evaluated for monoamine oxidase activity using both... 

A comparative study of the oxidation of a series of amines by liver preparations from different species and some Michaelis constants are shown in Table II. Kinetic and inhibitor specificity studies of monoamine oxidase systems have been reported. ... 

Other Effects of Cadmium on the Central Nervous System. Cadmium may affect the activity of certain enzymes in the brain. Adenylate cyclase activity in the rat cerebrum, cerebellum, and brain stem vv as inhibited in vitro by micromolar concentrations of cadmiumMonoamine oxidase, which is involved in the catabolism of transmitter monoamines, was also lowered in activity by cadmium in vitro A comparative study of the effects of cadmium and zinc on cholinesterase activity in the brain showed that cadmium activated cholinesterase, whereas zinc reduced this enzyme after acute intoxication. Following chronic exposure to both metals, the cholinesterase activity was not significantly altered. ... 

---