Molecularly imprinted solid phase extraction MISPE

Anderson RA et al (2008) Comparison of molecularly imprinted solid-phase extraction (MISPE) with classical solid-phase extraction (SPE) for the detection of benzodiazepines in post-mortem hair samples. Forensic Sci Int 174(1) 40 16... 

Molecularly imprinted solid-phase extraction (MISPE) is widely used for selective extraction of pharmaceuticals in variety of matrices (Rao et al, 2011 Javanbakht et al, 2010). The potential value of MISPE lies in the ability to selectively isolate specific compounds or their structural analogues from a complex matrix. The application of MIPs as sorbents allows not only preconcentration and cleaning of the sample but also selective extraction of the target analyte, which is important, particularly when the sample is complex and impurities can interfere with the quantification. 

Molecular imprinted polymer microspheres against enrofloxacin have been developed and off-line molecular imprinted solid-phase extraction (MISPE) has been applied for the extraction of enrofloxacin from bovine milk.t""i... 

Qiao and co-authors reported a new molecularly imprinted solid-phase extraction (MISPE) procedure combined with liquid chromatography for the simultaneous selective extraction and determination of ofloxacin (OFL) and lomefloxacin (LOM)... 

MISPE Molecularly imprinted solid phase extraction... 

A molecularly imprinted column for liquid chromatography can be used not only to separate analytes, but also to selectively extract analytes from complex samples. This technique is called on-line Molecularly Imprinted Solid Phase Extraction (on-line MISPE), and it combines the high extraction efficiency of reverse phase SPE for aqueous samples with the high selectivity of the molecular-imprinted polymers. Examples of successful selective extraction and clean-up are reported in Figs. 9 and 10. 

The application of MIPs as the stationary phase in solid-phase extraction (SPE), often referred to as molecularly imprinted polymer solid-phase extraction (MIS P E), is a rapidly growing area [197-199]. With MISPE, highly specific enrichment of substances present at trace levels is possible. The technique has been applied to the analysis of drugs, for example, caffeine [200], scopolamine [201], naproxen [202], tetracycline [203], cholesterol [204] and local anesthetics [205], as well as environmental pollutants, exemplified by organophosphate flame retardants [206-208], triazines in soil and vegetable samples [71] and naphthalene sulfonates in river water [209]. 

---