Molecularly imprinted polymers applications

Chapuis F et al (2004) Retention mechanism of analytes in the solid-phase extraction process using molecularly imprinted polymers - application to the extraction of triazines from complex matrices. J Chromatogr B Anal Technol Biomed Life Sci 804(1) 93-101... 

The development of highly selective chemical sensors for complex matrixes of medical, environmental, and industrial interest has been the object of greate research efforts in the last years. Recently, the use of artificial materials - molecularly imprinted polymers (MIPs) - with high recognition properties has been proposed for designing biomimetic sensors, but only a few sensor applications of MIPs based on electrosynythesized conductive polymers (MIEPs) have been reported [1-3]. 

Yano, K. and Karube, I., Molecularly imprinted polymers for biosensor applications. Trends Anal. Chem., 18, 199, 1999. 

Diaz-Garcia M.E., Badia R., Molecularly imprinted polymers for optical sensing devices" in Optical Sensors Industrial, Environmental and Diagnostic Applications, R. Narayanaswamy, O. S. Wolfbeis, (Eds.), Springer, 2004. 

Molecularly imprinted polymers (MIPs) are of growing interest for their potential biotechnological applications. Recently, the templating processes with living yeast cells were reported107 for the preparation of ordered and... 

The application of biosensors for process monitoring has been dogged by problems with fouling, selectivity, degrading bioactivity and long-term stability. Recent developments in molecularly imprinted polymers (MIPs) show some promise as synthetic receptors and have been used for this purpose for assays and as HPLC stationary phases. Recent work has shown that MIPs show increased robustness, storage endurance and lower cost compared with biosensors, which... 

SeUeTgren,B.,Molecularly Imprinted Polymers—Man-Made Mimics of Antibodies andTheir Applications in Analytical Chemistry, Elsevier, Amsterdam, the Netherlands, 2001. 

Piletsky SA, Terpetschnig E, Andersson HS, Nicholls lA, Wolfheis OS. Application of nonspecific fluorescent dyes for monitoring enantio-selective ligand binding to molecularly imprinted polymers. Fresenius J Anal Chem 1999 364 512-516. 

Sellergren B. Molecularly imprinted polymers man-made mimics of antibodies and their applications in anal3dical chemistry. New York Elsevier 2001b. 

Fig. 3 Application of the Doehlert experimental design to optimize a MIP for propranolol with respect to the type of cross-linker (EDMA or TRIM) and the degree of cross-linking, (a) Three-dimensional representation of response surfaces for the percentage of bound [3H]propanolol to the molecularly imprinted polymer (MIP) and the corresponding non-imprinted control polymer (NIP), (b) Contour plot of the function describing binding of [3H]propanolol to MIPs relative to the degree and the kind (bi or trifunctional) cross-linking. The values were corrected for non-specific binding to the non-imprinted control polymer. Adapted from [31] with kind permission from Springer Science + Business Media...

Molecularly imprinted polymers (MIPs) have been used in many different applications, such as affinity separation matrices [6, 7], antibody mimics in immunoassays [8-11], recognition elements in biosensors [12-16], selective... 

Applications of Molecularly Imprinted Polymers in Immuno-Like Assays.135... 

Ansell RA (2005) Applications of MIPs as antibody mimics in immunoassays. In Yan M, Ramstrom O (eds) Molecularly imprinted polymers science and technology. Marcel Dekker, New York... 

Abstract Most analytical applications of molecularly imprinted polymers are based on their selective adsorption properties towards the template or its analogs. In chromatography, solid phase extraction and electrochromatography this adsorption is a dynamic process. The dynamic process combined with the nonlinear adsorption isotherm of the polymers and other factors results in complications which have limited the success of imprinted polymers. This chapter explains these problems and shows many examples of successful applications overcoming or avoiding the problems. 

Sellergren B (ed) (2001) Molecularly imprinted polymers man-made mimics of antibodies and their applications in analytical chemistry, 1st edn. In Techniques and instrumentation in analytical chemistry, vol 23. Elsevier, Amsterdam... 

Caro E et al (2006) Application of molecularly imprinted polymers to solid-phase extraction of compounds from environmental and biological samples. TrAC, Trends Anal Chem 25(2) 143-154... 

Maier NM, Lindner W (2007) Chiral recognition applications of molecularly imprinted polymers a critical review. Anal Bioanal Chem 389(2) 377-397... 

Haginaka J, Sanbe H (2000) Uniform-sized molecularly imprinted polymers for 2-arylpro-pionic acid derivatives selectively modified with hydrophilic external layer and their applications to direct serum injection analysis. Anal Chem 72(21) 5206-5210... 

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