Molecular-weight centrifugation

Some slurry processes use continuous stirred tank reactors and relatively heavy solvents (57) these ate employed by such companies as Hoechst, Montedison, Mitsubishi, Dow, and Nissan. In the Hoechst process (Eig. 4), hexane is used as the diluent. Reactors usually operate at 80—90°C and a total pressure of 1—3 MPa (10—30 psi). The solvent, ethylene, catalyst components, and hydrogen are all continuously fed into the reactor. The residence time of catalyst particles in the reactor is two to three hours. The polymer slurry may be transferred into a smaller reactor for post-polymerization. In most cases, molecular weight of polymer is controlled by the addition of hydrogen to both reactors. After the slurry exits the second reactor, the total charge is separated by a centrifuge into a Hquid stream and soHd polymer. The solvent is then steam-stripped from wet polymer, purified, and returned to the main reactor the wet polymer is dried and pelletized. Variations of this process are widely used throughout the world. 

Compressor Configuration To propeny design a centrifugal compressor, one must know the operating conditions—the type of gas, its pressure, temperature, and molecular weight. One must also know the corrosive properties of the gas so that proper metallurgical selection can be made. Gas fluctuations due to process instabilities must be pinpointed so that the compressor can operate without surging. 

Molecular weight, effect on centrifugal sizing, 159 Mollier charts, 27 Monitoring system, 356 Motor, 146 enclosure, 260 equations, 267 insulation, 257 locked rotor torque, 270 selection, 270 service factor, 262 starting characteristics, 270 starting time, 273, 274 synchronous vs induction, 265 variable frequency drives, 27/, 280 voltage, 258 Motors... 

High gas yield shows up as higher speed on the compressor (if centrifugal). In many cases, lower molecular weight (due to higher hydrogen content) can have the same effect. 

When appreciable amounts of pectin, proteins, lipids, unwanted polyphenols, or other compounds are suspected to be present in anthocyanin-containing extracts, some of them can be precipitated or the anthocyanins may be crystalhzed and separated from the others. Pectin and proteins can be removed by organic solvents such as methanol and acetone in order to reduce their solubility, then precipitated and separated by centrifugation. Gelatin was used to remove proanthocyanidin due to its high molecular weight. Anthocyanins were reported to be precipitated early by lead acetate to achieve isolation from other materials. ... 

Filtration of the catalytic mixture using pore membrane filters or filter aids allows the distinction between soluble and insoluble catalysts. Further catalytic activity analysis from the solution and insoluble residue can give information about the state of the real catalyst. In turn, centrifugation can be appropriated to separate metal NPs from the catalytic solutions, due to their high molecular weight and density, and thus to be separated from molecular species. 

Until this point, the sample preparation techniques under discussion have relied upon differences in polarity to separate the analyte and the sample matrix in contrast, ultraflltration and on-line dialysis rely upon differences in molecular size between the analyte and matrix components to effect a separation. In ultrafiltration, a centrifugal force is applied across a membrane filter which has a molecular weight cut-off intended to isolate the analyte from larger matrix components. Furusawa incorporated an ultrafiltration step into his separation of sulfadimethoxine from chicken tissue extracts. Some cleanup of the sample extract may be necessary prior to ultrafiltration, or the ultrafiltration membranes can become clogged and ineffective. Also, one must ensure that the choice of membrane filter for ultrafiltration is appropriate in terms of both the molecular weight cut-off and compatibility with the extraction solvent used. 

---