Twist sense bias

Introduction of a Twist Sense Bias to the Folded State.118... 

Fig. 23 Solvent denaturation curves of 45 measured by a the UV absorbance ratio A303M287 and b the circular dichroism (g bs at 316 nm) showing the need for higher vol% acetonitrile to bring about twist sense bias than that needed for folding...

In an effort to impart a stronger twist sense bias on the mPE helix, a chiral binaphthol derivative was placed directly into the mPE backbone [64]. The chiral binaphthol unit was placed both at the center (47) and terminus (48) of the oligomer in order to determine how the position of the chiral unit would affect the twist sense bias and folded state stability. Solvent denaturation studies (UV... 

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