Molecular phenotyping

In close analogy with this biological definition, we will designate as molecular phenotype the ensemble of observable and computable properties of a chemical entity. These indeed are the observable expression of the core features of the... 

Fig. 1.2 Properties revealed by low-energy exchanges belong to the molecular phenotype , as exemplified here. This is contrasted with some other chemical properties (e.g. reactivity) which involve the...

Williams MC. Alveolar type I cells molecular phenotype and development. Annu Rev Physiol 2003 65 669-695. 

Sehl PD et al. Application of cDNA mi-croarays in determining molecular phenotype in cardiac growth, development, and response to injury. Circulation 2000 101 1990-1999. 

Table 13-1. Molecular phenotypes of autosomal dominant disease. ...

Schadt EE, Monks SA, Friend SH. A new paradigm for drug discovery integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochem Soc Trans 2003 31 437 43. 

Suslov, O.N., Kukekov, V.G., Ignatova, T.N., Steindler, D.A. (2002). Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres. Proc Natl Acad Sc,. USA 99, 14506-11. 

Holst, B., Hastrup, H., Raffetseder, U., Martini, L., and Schwartz, T. W. (2001). Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis. / Biol. Chem. 276, 19793-19799. 

CW Fisher, JL Chuang, TA Griffin, KS Lau, RP Cox, DT Chuang. Molecular phenotypes in cultured maple syrup urine disease cells complete El-a cDNA sequence and mRNA and subunit contents of the human branched chain a-keto acid dehydrogenase complex. J Biol Chem 264 3448-3453, 1989. 

Molecular Phenotypes of Concentric and Eccentric Cardiac Hypertrophy... 

Iemitsu, M., Miyauchi, T., Maeda, S., Sakai, S., Kobayashi, T., Fujii, N., Miyazaki, H., Matsuda, M., and Yamaguchi, I. 2001. Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat. Am. J. Physiol. 281 R2029-R2036. 

RNA secondary structures provide a kind of toy universe that allows to study the mapping of genotypes into molecular phenotypes in great detail. Three global relations between RNA sequences and structures were found to be important for evolution ... 

Rivera A, Alberti I, Martin AB, Narvaez JA, de la Calle A, Moratalla R (2002a) Molecular phenotype of rat striatal neurons expressing the dopamine D5 receptor subtype. Eur J Neurosci 76 2049-2058. 

Disease Mutant protein/protein involved Molecular phenotype... 

Taste begins with molecular events at the surface membranes of modified epithelial cells, which share many characteristics with neurons. Taste receptor cells are organized within specialized structures—taste buds— on the tongue and other parts of the oral cavity [for reviews see Kinnamon (1987), Reutter and Witt (1993)]. As described later, taste buds contain cells of different types, which can be distinguished on the basis of their ultrastructure and their molecular phenotypes. 

Challenge of two lines of transgenic mice expressing human PrP with M at codon 129 with L-type isolates produced a molecular phenotype distinct from classical BSE [63, 64], In one case, L-type transmitted with no transmission barrier [63], and in both cases the L-type PrPSc biochemical signature was conserved upon transmission. In contrast, the transmission efficiency of classical BSE and H-type isolates to transgenic mice expressing human PrP is relatively low [28, 63, 65],... 

Wiseman SM, Melck A, Masoudi H, et al. Molecular phenotype of thyroid tumors identifiers A marker panel for differentiated thyroid cancer diagnosis. Am Surg Oncol. 2008 15 2811-2826. 

Giangreco A, Shen H, Reynolds S D, et al. (2004). Molecular phenotype of airway side population cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 286 L624-630. 

More than 100 oncogenes and 15 tumor suppressor genes have been linked to cancer. The same approach can be used in the characterization and care of biochemical abnormalities in the mentally ill. The top-down approach is to examine the psychological phenotypes of an individual and search for abnormal genes or molecular phenotypic processes. The bottom-up approach is to identify mutated genes and then search for their abnormal expression. 

Schonberger, S. J., P. F. Edgar, et al., 2001, Proteomic analysis of the brain in Alzheimer s disease molecular phenotype of a complex disease process. Proteomics 1 1519-28. 

Garcia-Moruja, C., Rueda, P., Torres, C., Alcami,)., Luque, F., and Caruz, A. (2009) Molecular phenotype of CXCL12beta 3 UTR G801A polymorphism (rsl801157) associated to HIV-1 disease progression. Current HIV Research, 7, 384-389. 

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