Molecular basis of diseases

Sakwe, A.M. and Titanji, V.P.K. (1997) Evidence for increased hydroxylation of pyrrolidone amino acid residues in the cuticle of mature Onchocerca volvulus. Biochimica et Biophysica Acta- Molecular Basis of Disease 1360, 196-202. 

Green PS, Leeuwenburgh C (2002) Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis. Biochimica et Biophysica Acta-Molecular Basis of Disease 1588 94-101. 

E. Bloemena, S. Meljer, G. Jansen, C.J. van Groeningen, H.M. Pinedo, Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism, Biochem. Biophys. Acta (Molecular Basis of Disease) 1587 (2002) 194-205. 

The in vitro screening approach measures direct mechanistic links between chemical interactions with key targets and the downstream effects of perturbing the related molecular pathways. By using current knowledge ofthe molecular basis of diseases, one can enrich an assay set to probe targets in key disease-related pathways and thereby develop predictive models in a more hypothesis-driven manner. 

Erophylaxis of cardiac diseases, multiple sclerosis, several types of cancer, epatitis, arthritis, and diabetes, among others. Since biopharmaceuticals focus their action on the molecular basis of diseases, they are providing physicians and patients with new powerful tools for the treatment of diseases, changing fundamentally the way diseases are treated (PhRMA, 2004). 

Capello D, Rossi D, Gaidano G. Post-transplant lymphoproliferative disorders molecular basis of disease histogenesis and pathogenesis. Hematol Oncol 2005 23 61-7. 

In summary, the marine environment contains a wealth of plants, animals and microorganisms. Due to their unique adaptations to their ocean habitat, they contain a wide diversity of natural products. These compounds have shown activity in a variety of assays which have relevance to human diseases. As our understanding of the molecular basis of disease expands, these compounds and ones yet to be discovered will provide lead compounds for human therapeutic treatment. Innovations in synthesis, fermentation of symbionts as well as in manipulation of biosynthetic genes will allow us to produce sufficient material for clinical use of the compounds. Marine organisms provide a unique opportunity for access to chemical diversity. 

The sequencing of the human genome has brought about a systematic means of viewing the molecular basis of disease through genes and their many... 

Molecular diseases were discovered only fifteen years ago. Much has been learned since, but the possibilities for further discovery are tremendous. Knowledge that may be obtained in the near future about the molecular structure of the human body and the molecular basis of disease may well lead to a great decrease in the amount of human suffering. 

Molecular basis of disease Mutation resulting in an increased number of CGG repeats on the X chromosome. When the nnmber of repeats reaches a critical size, it can be methylated and inactivated resulting in the disorder. Individuals who carry 50 to 199 repeats are phenotypically normal and carry a premutation. If repeats exceed 200, the patient has a full mutation and if methylation occurs, he or she will be affected. 

In order to set the stage for this two-volume book, this Chapter provides an introduction into the molecular basis of disease. We then continue to discuss modern biological techniques with which we have recently been empowered to screen for molecular drugs targets as well as for the drugs themselves. The Chapter finishes with an overview over the field of bioinformatics as it is covered in the two volumes of this book. 

How does all this affect computational chemistry Pharmaceutical researchers must use every available tool to solve the health problems of today. And the tools for drug discovery must be more powerful than those available traditionally. More detailed knowledge of the molecular basis of disease means that a treatment may be found more readily. How are these molecular processes modeled and visualized The answer is computational chemistry. In industrialized countries today, every research-based pharmaceutical company has a computational chemistry effort. 

Fruhwirth, G O, Loidl, A, and Hermetter, A, Oxidized phospholipids From molecular properties to disease, Biochim. Biophys. Acta - Molecular Basis of Disease 1772 (2007) 718-736. 

The discovery of molecular diseases was made only about 25 years ago, and with each passing year more information becomes available about the molecular basis of disease. In the course of time investigations along these lines should lead to important advances in controlling disease and decreasing the amount of human suffering. 

Work conducted in the authors lab was supported by the National Institutes of Health (GM086925 and GM084933) and Georgia State University Molecular Basis of Disease (MBD) program (YFC). 

Alves, M.G., Martins, A.D., Rato, L., Moreira, P.I., Socorro, S., and Oliveira, P.F. 2013. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochi-mica et Biophysica Acta (BBA)—Molecular Basis of Disease, 1832 626-635. 

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