Molecular drug targets

Accord B, Espina V, Giordan M et al (2010) Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL. PLoS One (Electronic Resource) 5 el3552... 

Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature the key role of tumor-selective macro-molecular drug targeting. Adv Enzyme Regul 41 189-207... 

In order to set the stage for this two-volume book, this Chapter provides an introduction into the molecular basis of disease. We then continue to discuss modern biological techniques with which we have recently been empowered to screen for molecular drugs targets as well as for the drugs themselves. The Chapter finishes with an overview over the field of bioinformatics as it is covered in the two volumes of this book. 

Drews, J., Ryser, S. Molecular drug targets and genomic sciences. Nat. Biotechnol. 1997, 15, 1350-1359. 

The ideal molecular drug target is one which has been discovered in-house and is proprietary. Alternatively, a receptor or enzyme discovered by a researcher at a university, the cDNA of which is available for licensing by the drug company, could also provide an effective and proprietary target. These targets are often discovered serendip-itously, or could be the result of extensive fishing... 

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