Modified poly microspheres

Lao L, Tan H, Wang Y et al (2008) Chitosan modified poly(l-lactide) microspheres as cell microcarriers for cartilage tissue engineering. Colloids Surf B Biointerfaces 66 218-225... 

Figure 73 Representative 3-D nanostructured scaffolds for bone-specific drug delivery systems, (a) Electrospun sitk scaffold with BMP-2 loaded, scale bar=5 pm (reprinted from Ref. [86] with permission) (b) Self-assembled peptide-amphiphile (PA) nanofibers network, scale bar= 1 mi (reprinted from Ref. [87] with permission) (c) Nanocrystalline apatite modified poly(lactide-co-glycolide) (PLAGA) microsphere scaffolds, scale bar=2pm (reprinted from Ref. [88] with permission) and (d) poly(L-lactic acid) (PLLA) nanofibrous scaffolds incorporated with poly(lactic-co-glycolic acid) (PLGA) nanospheres, scale bar=2 pm (reprinted from Ref. [89] with permission).

Florindo, H. R, S. Pandit, L. M. D. Goncalves, H. O. Alpar, and A. J. Ahneida. 2008. Streptococcus equi antigens adsorbed onto surface modified poly-epsilon-caprolactone microspheres induce humoral and cellular specific immune responses. Vaccine 26 (33) 4168-4177. 

C. Tao, J. Huang, Y. Lu, H. Zou, X. He, Y. Chen, and Y. Zhong, Development and characterization of GRGDSPC-modified poly (lactide-co-glycolide acid) porous microspheres incorporated with protein-loaded chitosan microspheres for bone tissue engineering. Colloid. Surface. B Biointerfaces, 122,439-446,2014. 

Garkhal, K., Verma, S., Tikoo, K., Kumar, N. Surface modified poly(L-lactide-co-e-caprolactone) microspheres as scaffold for tissue engineering. J. Biomed. Mater. Res., Part A 82A,747-756(2007)... 

Microspheres and nanoparticles often consist of biocompatible polymers and belong either to the soluble or the particle type carriers. Besides the aforementioned HPMA polymeric backbone, carriers have also been prepared using dextrans, ficoll, sepharose or poly-L-lysine as the main carrier body. More recently alginate nanoparticles have been described for the targeting of antisense oligonucleotides [28]. As with other polymeric carrier systems, the backbone can be modified with e.g. sugar molecules or antibody fragments to introduce cellular specificity. 

Musial, W., Voncina, B., Pluta, J., Kokol, V., 2012. The Study of release of chlorhexidine from preparations with modified thermosensitive poly-N-isopropylacrylamide microspheres. Scientific World Journal 2012. 

T. He, Q. Liang, K. Zhang, X. Mu, T. Luo, Y. Wang, and G. Luo, A modified microfluidic chip for fabrication of paclitaxel-loaded poly(L-lactic acid) microspheres. Microfluidics and Nanofluidics, 10, 1289-1298, 2011. 

Zhu KJ, Jiang HL, Dn XY, Wang J, Xu WX, Liu SF. Preparation and characterization of hCG-loaded polylactide or poly(lactide-co-glycolide) microspheres using a modified water-in-oil-in-water (w/o/w) emulsion solvent evaporation technique. Journal of Microencapsulation. March-April 2001 18(2) 247-260. PubMed PMID 11253941. 

In this chapter, we introduce the ESA modified membranes by forming electrostatic alternate layers of cetyl trimethyl ammonium chloride (CTAC) and poly(acrylic acid) (PAA) onto charged copolyacrylonitrile membranes (Scheme 1). Along with surface characterization of the ESA multilayer, infrared analysis was carried out. Finally, we evaluated the adsorptive properties of ESA multilayer for Fe and Fe, and ESA membranes with chitosan microspheres / PAA for removing of Cu2+. 

A recent report describes the in situ polymerization of MMA on modified cadmium sulfide (CdS) nanocrystals (NCs) along with copolymers using poly(methacryloxypropyltrimethoxysi-lane) (PMPS). The terminal functional groups on the surface were then cross-linked by free radical polymerization to form CdS NC-polymer networks. This work has been continued with incorporation of poly(styrene)-co-poly(methactylic acid) microspheres by surfactant-free emulsion polymerization. 

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