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Moderate-acting amide

Example Lidocaine (Xylocaine) Moderate-acting amide (1-3 hours) Route IM/SC/I V Topical Pregnancy category B Pharmacokinetic Metabolized in liver PB 60%-80% ... [Pg.205]

Asymmetric amidation of sp C—H bonds was reported in good yields and moderate enantioselectivities (Scheme 5.27)." ° When benzylic or allylic C—H bonds were used, similar results were also obtained." In these reactions the prepared nitrenes, PhI=NTs, and/or PhI(OAc)2+NH2Ts were used as nitrogen atom transfer sources. The studies showed that Ru=NTs was formed in situ and acted as a possible active intermediate when a ruthenium catalyst was used (Figure 5.12), whereas a radical intermediate might be involved when a manganese catalyst was used. [Pg.144]

Esters, tertiary amides, and nitriles are frequently used as solvents for organic reactions because they provide a polar reaction medium without O—H or N—H groups that can donate protons or act as nucleophiles. Ethyl acetate is a moderately polar solvent with a boiling point of 77 °C, convenient for easy evaporation from a reaction mixture. Acetonitrile, dimethylformamide (DMF), and dimethylacetamide (DMA) are highly polar solvents that solvate ions almost as well as water, but without the reactivity of O—H or N—H groups. These three solvents are miscible with water and are often used in solvent mixtures with water. [Pg.990]

Binding of iron by dietary fiber is strongly inhibited by ascorbic acid, citrate, cysteine, EDTA or phytate in concentrations as lew as 100 >uMols/Liter (A3). The inhibitors have the common property of being able to form soluble complexes with iron. The decarbox-ylic amino acids and their amides inhibit binding moderately as do lysine and histidine. Other amino acids either do not interfere with binding of iron fiber or do so only weakly. Calcium (as acetate) and phosphate act as moderate inhibitors. The detergents sodium lauryl sulfonate or cetyltrimethylammonium bromide had no effect on iron binding by fiber (A2). [Pg.147]

The conorfamides, isolated from Conus spurius, belong to the RFamide neuropeptide family and may act as an agonist of the FMRF-amide-gated ion channels. In invertebrates, this peptide family has many diverse functions, whereas in the mammalian system they moderate opioid function in the CNS, modulate epithelial Na" " channels, have important cardiovascular effects, and stimulate pancreatic somatostatin secretion. ... [Pg.521]


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See also in sourсe #XX -- [ Pg.192 ]




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