RFamide neuropeptides

The conorfamides, isolated from Conus spurius, belong to the RFamide neuropeptide family and may act as an agonist of the FMRF-amide-gated ion channels. In invertebrates, this peptide family has many diverse functions, whereas in the mammalian system they moderate opioid function in the CNS, modulate epithelial Na" " channels, have important cardiovascular effects, and stimulate pancreatic somatostatin secretion. ... 

FMRFamide-related peptides (FaRP), term for neuropeptides with C-terminal sequence similarities to FMRFamide. Nowadays, FaRP are very often included in the family RFamide peptides. 

Moosler, A., Rinehart, K.L., and Grimmelikhuijzen, J.P. (1997) Isolation of three novel neuropeptides, the Cyanea-Rfamides 1-111, from Scyphomedusae. Biochem. Biophys. Res. Commun., 236, 743-749. 

---