Model Rubinstein

Rubinstein, A.L., Zebrafish from disease modeling to drug discovery, Curr. Opin. Drug Discov. Dev., 6, 218-223, 2003. 

Figure 3. The many ways to lose a HAT. Decreased amounts of functional CBP protein and subsequent CBP s loss of function has been observed in different contexts of neurological disorders and neuronal apoptosis. RTS (Rubinstein-Taybi Syndrome) results from a mutation on one cbp gene allele. In several cases of polyQ diseases, CBP can be sequestred by the mutated polyQ proteins, forming aggregates in the cytoplasm or the nucleus. CBP proteasomal degradation was also shown to be favored by polyQ proteins. CBP is a caspase-6 substrate in cerebellar granule neurons (CGN) deprived of potassium modeling caspase-dependent apoptosis. Finally, cbp gene repression has been observed in oxidative stress-induced death of a motomeuronal cell line. The mechanisms by which CBP levels are reduced in motomeurons of ALS mice is still unknown...

Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A (2004) Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42(6) 947-959 Alnernri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J (1996) Human lCElCED-3 protease nomenclature. Cell 87(2) 171... 

Boris D, Rubinstein M. A self-consistent mean held model of a starburst dendrimer dense core vs dense shell. Macromolecules 1996 29 7251-7260. 

Recent approach using the anisotropic singular perturbation is the article by Mikelic et al. (2006). This approach gives the error estimate for the approximation and, consequently, the rigorous justification of the proposed effective models. It uses the strategy introduced by Rubinstein and Mauri (1986) for obtaining the effective models. 

In this section, we will obtain the non-dimensional effective or upscaled equations using a two-scale expansion with respect to the transversal Peclet number Note that the transversal P let number is equal to the ratio between the characteristic transversal timescale and longitudinal timescale. Then we use Fredholm s alternative to obtain the effective equations. However, they do not follow immediately. Direct application of Fredholm s alternative gives hyperbolic equations which are not satisfactory for our model. To obtain a better approximation, we use the strategy from Rubinstein and Mauri (1986) and embed the hyperbolic equation to the next order equations. This approach leads to the effective equations containing Taylor s dispersion type terms. Since we are in the presence of chemical reactions, dispersion is not caused only by the important Peclet number, but also by the effects of the chemical reactions, entering through Damkohler number. 

T. Erneux and I. Rubinstein, Hopf bifurcation in a local model of Teorell oscillations, to appear. 

Figure 4.11 Effect of SAM formation on the cyclic voltammetry of ferrocenylmethyltrimethylam-monium on a polycrystalline gold electrode the supporting electrolyte is 0.5 M H2SO4, with a scan rate of 0.1 V s-1. Curve (a) is the reversible cyclic voltammogram obtained on bare gold, while curves (b)-(d) are obtained on the same electrode with different monolayers (for details see text). The symbols represent theoretical fits to a microarray electrode model. Reprinted with permission from H.O. Finklea, D.A. Snider, J. Fedyk, E. Sabatani, Y. Gafni and I. Rubinstein, Langmuir, 9,3660 (1993). Copyright (1993) American Chemical Society...

Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, Schepartz S, Kalyandmg S, Christian M, Arbuck S, Hollingshead M, Sausville EA. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br J Cancer 2001 84 1424-31. 

Several techniques have been used to estimate the rate of mucus secretion, but their accuracy seems to be doubtful. Nevertheless, it has been concluded that a slow baseline secretion of mucus is maintained by exocytosis from goblet cells in the gastrointestinal tract, which appears to be under cholinergic control. Rubinstein and Tirosh used carbachol (cholinergic agonist) at different doses to increase the mucus thickness in different parts of the gastrointestinal tract. Attempts were also made to estimate the rate of turnover of the mucus gel. Lehr et al. measured the amount of mucus produced per time unit, using an in situ perfused intestinal loop model in the rat. They found that this turnover time varies between... 

Comparison of the non-affine slip-tube model [Eq. (7.65) using Gx and as adjustable parameters] with experiments, see M. Rubinstein and S. Panyukov, Macromolecules 35, 6670... 

Viscosity of linear polymer calculated from Monte Carlo simulations. Filled circles are repton model data from M. Rubinstein, Phys. Rev. Lett. 59,1946 (1987), with data range extended by D. Shirvanyants and open squares are Evans-Edwards model data from J. M. Deutsch and T. L. Madden,... 

More recently, there has been renewed interest in confined atomic systems in several areas of research for reviews and references see Jaskolski [7], Sako and Diercksen [8,9] and Dolmatov et al. [10], as well as papers here in the present volume. In addition to the spherical box model, the hydrogen atom has also been studied under various types of confinement (see, for example, Ley-Koo and Rubinstein [4], Froman et al. [5], Connerade et al. [11] and Saha et al. [12]), and off-centre investigations of the spherical cavity model have been performed as well [13]. 

Alarcon JM et al (2004) Chromatin acetylation, memory, and LTP are impaired in CBP+/— mice a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42(6) 947-959... 

Lake, J.L., Rubinstein, N. Pavignano, S. (1987) Predicting bioaccumu-lation Development of a simple partitioning model for use as a screening tool for regulating ocean disposal of wastes. Fate and Effects of Sediment-Bound Chemicals in Aquatic Systems, eds. K.L. Dickson, A.W. Maki W.A. Brungs, pp. 151-166. New York Pergamon Press. 

An important support of the sextet model was obtained by Rubinstein et al. (209) they found that catalytical activity for dehydrogenation of cyclohexane falls regularly with the decrease of the intensity of X-ray reflections from the (HI) facets of platinum on coal. 

From these encouraging results, we can attempt a more molecular interpretation and fit our uniaxial extension data to a molecularly based model such as that proposed by Rubinstein and Panyukov [50], which was developed to model crosslinked rubbers. 

A particularly interesting molecular model for the nonlinear elasticity of polymer networks was proposed by Rubinstein and Panyukov [50], the slip-tube model. In this model the confining potential acting on the network chains depends on the deformation and is modeled by virtual chains attached to the network... 

Rubinstein, R. Y. and Shapiro, A. (1990), Optimization of Static Simulation Models by the Score Function Method, Mathematics and Computers in Simulation, Vol. 32, pp. 373-392. 

Graessley and Struglinski, 1986 Green and Kramer, 1986 Green et al., 1984 Liu et al., 2006 Rubinstein and Colby, 1988 Viovy et al., 1991), and the faster process controls properties such as diffusivity and viscosity. A model based on a similar principle has also been proposed for the diffusion of CPs in a CLB (Klein, 1986). 

Rubinstein, M. 1985. Nonparametric Tests of Alternative Option Pricing Models. 

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