Mitogen inducible genes

Saarikoski ST, Rivera SP, Hankinson O. Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia. FEBS Lett 2002 530 186-190. 

Lin Ci DuJ, Shen WT, Whang EE, Donner DB, Griff N, He F, Jar Moor FD, Clark OH, Ruan DT. Mitogen-inducible gene-6 is a multifunctional adaptor protein with tumor suppressor-tike activity in papillary thyroid cancer. J Clin Endocrinol Metab. 2011 96 E554-65. 

Holden PR et al. Immediate-early gene expression during regenerative and mitogen-induced liver growth in the rat. J Biochem Toxicol 1998 12 79-82. 

Gamovskaya MN, Mukhin Y V, Vlasova TM, et al. Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. J Biol Chem 2004 279 24,899-24,905. 

Trichothecenes inhibit synthesis of protein, RNA and DNA as well as mitochondrial and electron transport chain function stimulate lipid peroxidation alter cell membrane function induce apoptosis modulate immune responses activate mitogen-activated protein kinases (MAPKs) and induce gene expression of numerous chemokines and cytokines and alter neurotransmitter levels. 

Glucocorticoids control IL-1 via inhibition of mitogen-induced transcription of the IL-ip gene and decreased stability of its mRNA in monocytes of several species (Knudsen et al. 1987, Lee et al. 1988, Amano et al. 1993, Huether et al. 1993). In contrast, the IL-1 receptor is induced by glucocorticoids in a protein and mRNA neosynthesis-dependent fashion (Akahoshi et al. 1988, Gott-SCHALL et al. 1991), as is the type n receptor, a potential decoy target for IL-1 (Re et al. 1994). 

Fletcher BS, Kujubu DA, Perrin DM, Herschman HR. Structure of the mitogen-inducible TISIO gene and demonstration that the TISlO-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem 1992 267 4338-4344. 

Activation of Mi, M3, and M5 mAChRs does not only lead to the generation of IP3 followed by the mobilization of intracellular Ca2+, but also results in the stimulation of phospholipase A2, phospholipase D, and various tyrosine kinases. Similarly, M2 and M4 receptor activation does not only mediate the inhibition of adenylyl cyclase, but also induces other biochemical responses including augmentation of phospholipase A2 activity. Moreover, the stimulation of different mAChR subtypes is also linked to the activation of different classes of mitogen-activated protein kinases (MAP kinases), resulting in specific effects on gene expression and cell growth or differentiation. 

Moon, Y. and Pestka J.J. Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. Toxicol. Sci. 69, 373, 2002. 

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