Mineral metabolism, disorders

R. S. Flueck, J. A. "The Interrelationships Between Vitamin D and Parathyroid Hormone in Disorders of Mineral Metabolism in Man" (Proceedings of 2nd Vitamin D Symposium), Weisbaden, West Germany, Oct., 1974, In Press. 

Dawson-Hughes, B. (2006a). Calcium and vitamin D. In "Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism" (M. J. Favus, ed.), pp. 257-259. The American Society for Bone and Mineral Research, Washington DC. 

Plicamycin is a cytotoxic antibiotic (see Chapter 54) that has been used clinically for two disorders of bone mineral metabolism Paget s disease and hypercalcemia. The cytotoxic properties of the drug appear to involve its binding to DNA and interruption of DNA directed RNA synthesis. The reasons for its usefulness in the treatment of Paget s disease and hypercalcemia are unclear but may relate to the need for protein synthesis to sustain bone resorption. The doses required to treat Paget s disease and hypercalcemia are about one tenth the amounts required to achieve cytotoxic effects. 

Bringhurst FR, Demay MB, Kronenberg HM. Hormones and disorders of mineral metabolism. In Larsen PR, et al, eds. Williams Textbook of Endocrinology. 10th ed. Philadelphia WB Saunders 2003. 

Alfrey AC. 1981. Aluminum and tin. In Bronner F, Cobum JW, eds. Disorders of mineral metabolism. Vol. 1. Trace minerals. New York, NY Academic Press, 353-368. 

Jergas M, Genant HK Radiologic imaging of metabolic bone disease, in Coe FL, Favus MJ (eds) Disorders of Bone and Mineral Metabolism. Lippincott Williams and Williams, Philadelphia, 2002, pp. 428-447. 

Mundy G. R. (1999) Bone remodeling. In Primer on the Metabolic Diseases and Disorders of Mineral Metabolism, 4th edn. (ed. M. J. Favus). Lippincott Wilhams and Wilkins, Philadelphia, pp. 30-38. 

Cole DEC, Carpenter TO, Goltzman D. Calcium homeostasis and disorders of bone and mineral metabolism. In CoUu R, Ducharna JR, Guyda HJ, editors. Pediatric Endocrinology. 2nd ed. New York Raven Press, 1989 509-80. 

Hahn TJ. Drug-induced disorders of vitamin D and mineral metabolism. Clin Endocrinol Metab 1980 9(l) 107-27. 

In this chapter, after an overview of bone and mineral metabolism, we discuss the clinical chemistry of calcium, phosphate, and magnesium the hormones regulating these minerals the major disorders of bone and the clinical use of markers of bone formation and degradation. A goal of the chapter is to provide, in one place, a view of these highly interrelated topics. 

Laboratory findings in rickets and osteomalacia include an increased serum ALP, with other alterations in bone and mineral metabolism dependent on the cause and severity of the disorder. ALP is usually increased because of the increased osteoblastic activity associated with producing unmineralized osteoid. Calcium may be low-normal or low in vitamin D deficiency depending on the severity of the disease. Phosphate may be normal or low, but falls with the development of secondary hyperparathyroidism. The serum calcium and PTH concentrations are usually normal in renal tubular defects of phosphate transport. Vitamin D nutrition may be assessed by the determination of serum 25(OH)D. Renal phosphate defects can be best assessed by determination of the renal phosphate threshold. 

Renal osteodystrophy includes all of the disorders of bone and mineral metabolism associated with chronic renal failure. The renal bone diseases include both... 

Endres DB, Adams JS. Vitamin D and metabolites, in Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. Kelseyville, Calif. American Society for Bone and Mineral Research, 1990 70-3. 

Favus M, ed. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. Washington, Cadmus Professional Communications, 2003. 

Disorders of Mineral Metabolism, pp. 413. Raven Press New York. 

FIGURE 61-2 Adapted, widi permission, from Yanagawa N, Lee DBN Renal handling of calcium and phosphorus. In Disorders of Bone and Mineral Metabolism. FL Coe, MJ Favus (eds). Philadelphia, Lippincott Williams Wilkins, 1992. 

Hahn TJ (1989) Aluminum-related disorders of bone and mineral metabolism. In Bone and Mineral Research. Vol. 6. Peck WA (ed) Elsevier, New York Hounslow AW, Chao GY (1968) Monoclinic chlorapatite from Ontario. Can Mineral 10 252-259 Hughes JM, Cameron M, Crowley KD (1989) Stmctural variations in natural F, OH and Cl apatites. Am Mineral 74 870-876... 

Gehron Robey P, Bianco P, Termine JD (1992) The cellular and biology and molecular biochemistry of bone formation. In Favus MJ, Coe EL (eds) Disorders of bone and mineral metabolism. Raven, New York... 

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