Mild hypotension

Myelosuppression is the major side effect of paclitaxel. Alopecia is common, as is reversible dose-related peripheral neuropathy. Most patients have mild numbness and tingling of the fingers and toes beginning a few days after treatment. Mild muscle and joint aching also may begin 2 or 3 days after initiation of therapy. Nausea is usually mild or absent. Severe hypersensitivity reactions may occur. Cardiovascular side effects, consisting of mild hypotension and bradycardia, have been noted in up to 25% of patients. 

Nervousness, fatigue, constipation, generalized aches and pains, mild hypotension... 

Thiazides, due to their direct action on blood vessels and on sodium metabolism produce a mild hypotension. They also tend... 

Adverse effects are nausea, fever, mild hypotension, rash, pruritus and localised bleeding. 

There was an increase in blood pressure throughout 24 hours in a double-bhnd, placebo-controlled, crossover study in 47 hypertensive patients who were also taking nifedipine (10). This finding differs from other studies in which melatonin had a mild hypotensive effect (11) and may indicate an interaction between melatonin and nifedipine. Tachycardia, chest pain, and cardiac dysrhythmias have also been reported, although the relation to melatonin was not clearly established (5). 

Hypotension has been reported in two other elderly patients who were taking thioridazine (14). The patients, men aged 68 and 70 years, had traumatic brain injury and were taking oral thioridazine 25 mg/day for agitation. A few days later they developed mild hypotension (100/50 and 100/60 mmHg respectively). 

Intravenous injection can cause spasm of the gall-bladder neck and severe pain with tingling sensations, sweating, and mild hypotension (1). 

Early-stage elephantiasis caused by bancroftian filariasis in a 27-year-old traveller was treated with a single-dose oral combination of ivermectin 24 mg plus albendazole 400 mg, followed by albendazole 800 mg for 21 days (14). To avoid a severe Mazzotti-like reaction, he was given oral glucocorticoids and antihistamines for 3 days. He had a transient rash, pruritus, and mild hypotension on the days after the initial treatment, but otherwise remained well and the swelling subsided. Within 1 month he was free of symptoms. At the last follow-up examination, 3 years after treatment, there was no clinical or laboratory evidence of relapse. The authors thought that this type of treatment should be evaluated on a wider scale, given the minimal adverse events and apparent therapeutic efficacy. 

The adverse effects of propafenone in placebo-con-trolled trials in patients with atrial tachydysrhythmias have been reviewed (16). The following effects were reported after single intravenous oral doses to produce conversion of atrial fibrillation to sinus rhythm. Non-cardiac adverse effects included mild dizziness. Mild hypotension was also noted, but only required withdrawal of propafenone in one of 29 patients in one study. There have been prodysrhythmic effects in several studies, including atrial flutter with a broad QRS complex, which can occur in up to 5% of cases in some cases atrial flutter can have a rapid ventricular response due to 1 1 atrioventricular conduction, which has been attributed to slowing of atrial conduction and reduced refractoriness of the atrioventricular node. Other prodysrhythmic effects in a few patients included sinus bradycardia with sinus pauses and effects on atrioventricular conduction. 

A 68-year-old man received an accidental infusion of a 1% sodium hypochlorite solution. After 1 hour and an infusion volume of 150 ml the infusion was stopped. By this time he had a slow heart rate, mild hypotension,... 

Clinical signs of toxicity most frequently seen include sedation, coma, seizures, extrapyramidal effects, and rarely hypotension and cardiac arrhythmias. Coma and seizures may develop rapidly following an exposure to loxapine. Cardiac effects include prolonged QRS, Q-T intervals, and mild hypotension however, the cardiac effects are less pronounced than those associated with tricyclic antidepressants. Anticholinergic effects, including dry mouth, blurred vision, and tachycardia, have been seen. Neuroleptic malignant syndrome has been reported after therapeutic use and acute intoxication. Hypokalemia has also been noted. 

Clinical signs of toxicity most frequently include sedation, coma, hypotension, extrapyramidal effects, and cardiac arrhythmias. Anticholinergic effects including blurred vision, decreased gastrointestinal motility, delirium, hallucinations, hyperthermia, and tachycardia have been seen. Cardiac effects include mild hypotension, prolonged Q-T interval, and ventricular dysrhythmias. Quinidine-like effects have rarely resulted in sudden cardiac death. The most commonly reported extrapyramidal symptoms include dystonia, akathisia, and parkinsonism. Respiratory depression, loss of gag... 

Amiloride has mild hypotensive effects, which are beneficial in treatment of CHF. It is also potassium sparing, and may be useful as adjunct therapy with loop diuretics. 

Mild hypotension (systolic blood pressure of 70-90 mm Hg) in a patient with hypothermia shouid not be aggressively treated excessive intravenous fluids may cause fluid overload and further lowering of the temperature. 

Cardiovascular Mild hypotension because of vitamin K2 has been reported [92 ]. 

Hemostatic and mild hypotensive activities have been reported (bradly). In an in vitro study, the aqueous extract of U. dioica dose dependently inhibited thrombin-induced platelet aggregation. The observed effect has been attributed to the flavonoid constituents of the extract. The hypotensive effects of U. dioica extracts (aqueous and methanohc, in vivo and in isolated organs) have also been reported by more than one group and the mechanism of action is suggested to be through vasodilation mediated by nitric oxide release, potassium channel opening, and negative inotropic action. ... 

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