Mid-infrared laser ablation

Nelson, J.S., et al. 1991. Mid-infrared laser ablation of stratum comeum enhances in vitro percutaneous transport of drugs. J Invest Dermatol 97 874. 

Mid-infrared laser ablation of the SC has been used to allow the transdermal delivery of interferon-y. The mechanism by which this laser beam explodes away the SC is complex, yet quite reproducible and controllable, in that the number of laser pulses is correlated to the degree of SC damage (and hence to the peptide s permeability through the tissue). Tissue destruction below the SC appeared to be minimal. 

Several other ionization methods and MS technologies have been investigated for possible use for imaging. Atmospheric pressure infrared MALDI (AP IR-MALDI) and mid-infrared laser ablation with electrospray ionization (LAESI) have been reported and use focused laser radiation for ambient sampling with no sample preparation or chemical modification required. In these... 

Sripadi, P. Nazarian, J. Hathout, Y. Hoffman, E.P. Vertes, A. In Vitro Analysis of Metabolites from the Untreated Tissue of Torpedo Califomica Electric Organ by Mid-Infrared Laser Ablation Electrospray Ionization Mass Spectrometry. Metaholomics 2009, 5, 263-276. 

Novel ionization methods in ambient mass spectrometry (I) overcome these limitations by performing imaging under native conditions. Desorption electrospray ionization (2), atmospheric pressure (AP) mid-infrared (mid-IR) MALDI (3), laser ablation... 

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