Microsphere advantages

Water-in-od emulsion explosives have been made as typified by a formulation containing 20% water, 12% oil, 2% microspheres, 1% emulsifier, and 65% ammonium nitrate. The micro droplets of an emulsion explosive offer the advantage of intimate contact between fuel and oxidizer, and tend to equal or outperform conventional water-based slurries. 

At present there is no reason evident why poly(N-acylhydroxy-proline esters) should not be suitable for the formation of microcapsules or microspheres as well. For microencapsulated drug fonmula-tions the longer degradation times of poly(N-acylhydroxyproline esters) as compared to poly (lactic acid) could again be a distinctive advantage for long-term applications. 

The clever combination of chemistry and microsphere technology enables advertisers to take advantage of the incredible marketing power of scent. These innovations have also modernized paper-based recordkeeping and business transactions. 

The silica microspheres provide some diversity but not enough for many complex discrimination tasks. To introduce more sensor variety, hollow polymeric microspheres have been fabricated8. The preparation of these hollow microspheres involves coating silica microspheres by living radical polymerization, using the surface as the initiation site. Once the polymer layer forms on the silica microbead surface, the silica core is removed by chemical etching. These hollow spheres can be derivatized with the dye of interest. The main advantage of these polymer microspheres is the variety of monomers that can be employed in their fabrication to produce sensors with many different surface functionalities and polymer compositions. 

An advantage of this type of delivery system is that microspheres displaying different release profiles (e.g., being composed of different polymers or different sizes) can be combined in cocktails to obtain release profiles that are the sum of the various release profiles from the individual formulations (Kipper et al., 2002). Multiple drugs could also be delivered this way in a single injection. 

Another application of microparticle technology is the production of polymeric microspheres, which are usually produced by emulsion polymerization techniques. But a variety of polymer colloids can be made by aerosol techniques (Partch et al, 1983 Nakamura et al, 1984 Partch et al, 1985). One advantage of the aerosol route is that larger sizes can be attained... 

The main technological advantage of microspheres is that the viscosity of systems with spherical fillers is always less than that of a system with fillers of any other shape, because a sphere has the smallest surface. Moreover the isotropic materials with the best strength properties are those with spherical gas inclusions10). 

Liquid fluorocarbon was used as continuous phase by Perez-Moral and Mayes [19] as well. They proposed a new method for rapid synthesis of MIP beads, in that they prepared 36 polymers imprinted for propranolol and morphine with different amounts of EDMA as a cross-linker and different functional monomers (MAA, acrylic acid, hydroxyethyl methacrylate, 4-vinylpyridine) directly in SPE cartridges. The properties of MIP microspheres prepared by this method were very similar in terms of size, morphology and extent of rebinding to microspheres prepared by conventional suspension polymerisation in perfluorocarbons as well as to bulk polymers prepared in the same solvent. The most notable advantages of this method are no waste production (no transfer of beads during washing steps) and possible direct use for a variety of screening, evaluation and optimisation experiments. 

The geometry of the microelectrodes is critically important not only from the point of view of the mathematical treatment, but also their performance. Thus, the diffusion equations for spherical microelectrodes can be solved exactly because the radial coordinates for this electrode can be reduced to the point at r = 0. On the other hand, a microelectrode with any other geometry does not have a closed mathematical solution. It would be advantageous if a microdisc electrode, which is easier to fabricate, would behave identically to a microsphere electrode. This is not so, because the center of the disc is less accessible to the diffusing electroactive species than its periphery. As a result, the current density at this electrode is nonuniform. 

Microparticulate systems present the advantage, in comparison with single-unit solid systems, to guarantee a wider contact area between the drug and the mucosa. Different microparticulate systems intended for vaginal administration were developed they include liposomes, microcapsules, and microspheres. Such systems can possess intrinsic bioadhesive properties or can be loaded in a vehicle with bioadhesive properties. 

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