Microreactor synthesis

Flogel O, Codee JDC, Seebach D, Seeberger PH (2006) Microreactor Synthesis of Beta-Peptides. Angew Chem Int Ed 45 7000-7003 Geyer K, Codee JDC, Seeberger PH (2006) Microreactors as Tools for Synthetic Chemists - The Chemists Round-Bottomed Flask of the 21st Century Chem Eur J 12 8434-8442... 

The formation of more complex dipeptides was also demonstrated by micro-channel processing through the experiment of converting the amino acid N- -Boc-l-lysine with the additional amino function [5,6]. Although the batch yield is poor with only 9% yield, microreactor synthesis is quantitative in 20 min. 

For microreactor synthesis using electrochemically generated reactive species, see Yoshida, J. (2005) Chem. Commun., 4509. 

For the microreactor synthesis and precipitation, finer particles with more uniform size distribution were yielded for the commercial azo pigment Yellow 12 [31]. 

Table 9 Molecular weight and molecular weight distribution obtained in microreactor synthesis...

Nagaki A, Kim H, Yoshida J (2009) Nitro-substituted aryl lithium compounds in microreactor synthesis switch between kinetic and thermodynamic control. Angew Chem Int Ed 48 8063-8065... 

Nagald A, Yamada S, Doi M et al (2011) Flow microreactor synthesis of disubstituted pyridines from dibromopyridines via BrA i exchange without using cryogenic conditions. Green Chem 13 1110-1113... 

Yoshida J (2010) Flash chemistry flow microreactor synthesis based on high-resolution reaction time control. Chem Rec 10 332-341... 

FIdgel O, Codee JDC, Seebach D, Seeberger PH (2006) Microreactor synthesis of fl-peptides. Angew Chem Int Ed 45 7000-7003... 

Microfluidic reactor for polymer synthesis Polymerization reaction in microreactor Synthesis of polymer molecules using microfluidics... 

G. Panke, T. Schwalbe, W. Stimer, S. Taghavi-Moghadam, G. WiUe, A practical approach of continuous processing to high energetic nitration reactions in microreactors. Synthesis 2003, 38, 2827-2830. 

Brandt J.C., Wirth T. Controlling hazardous chemicals in microreactors synthesis with iodine azide. Beilstein J. Org. Chem. 2009 5(30). doi 10.3762/bjoc.5.30... 

The main theme of this book is flow microreactor synthesis, i.e., a chemical synthesis using a flow reactor having a microintemal space. Although researchers who have been accustomed to flasks and beakers can understand microreactors or smaller reactors relatively easily, they may find it diflicult to understand flow reactors. Therefore, this chapter describes how reactions proceed in flow reactors. 

Chapter 1 describes the need to depart from flask reactions that researchers have long been accustomed to and move our focus on flow reactions to understand flow microreactor synthesis. This chapter describes one of the specific characteristics of flow reactions, i.e, residence time, and explores how such a characteristic can be used in controlling chemical synthesis. 

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